Measurement of neurodevelopmental effects of prenatal alcohol exposure in Ukrainian preschool children.
Measurement of neurodevelopmental effects of prenatal alcohol exposure in Ukrainian preschool children.
复制标题
DOI：
10.1080/09297049.2021.1919298
复制
发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
产前酒精暴露（PAE）的影响很少测量学龄前儿童由于相对不敏感的评估方法在这个年龄。为了研究潜在的非语言电池在早期识别认知问题的酒精暴露的儿童，291前瞻性地确定乌克兰儿童进行了评估，使用测试电池专注于早期执行功能（EF）和视觉空间技能，认知发展领域特别敏感的PAE在年龄较大的儿童。测试包括区分能力量表，第二版（DAS-2）和几个NEPSY/NEPSY-II子测试，在美国标准化。其他人改编自常用的非标准化的神经心理学措施EF（学前空间跨度，模仿手游戏，A不是B，延迟注意，主题有序指向）。在乌克兰的两个地点，Rivne和Khmelnitsky，对3岁半至4岁半的儿童进行了测试，以确定PAE的影响。虽然大多数儿童的表现在平均范围内，酒精暴露的学龄前儿童有较低的DAS-II总分以及特定的子测试。为了评估酒精剂量在孕前识别期和妊娠中期的影响，使用广义线性回归模型控制人口统计学和个体变量。除了DAS-II变量外，反映持续注意力、工作记忆和转移认知能力的措施也受到酒精剂量的影响。早期的执行功能似乎substanbul这些性能差异。总之，研究结果表明，PAE的影响，可以确定在学龄前期间和可靠的测量使用测试评估非语言和空间技能的执行功能的支持。
Effects of prenatal alcohol exposure (PAE) are rarely measured in preschool children due to relative insensitivity of assessment methods at this age. To examine the potential of a nonverbal battery in early identification of cognitive problems in alcohol-exposed children, 291 prospectively identified Ukrainian children were evaluated using a test battery focusing on early executive functioning (EF) and visuospatial skills, areas of cognitive development particularly sensitive to PAE in older children. Tests included the Differential Ability Scales, 2nd Edition (DAS-2) and several NEPSY/NEPSY-II subtests, standardized in the United States. Others were adapted from commonly used non-standardized neuropsychological measures of EF (Preschool Spatial Span, Imitation Hand Game, A not B, Delayed Attention, Subject Ordered Pointing). Children in two sites in Ukraine, Rivne and Khmelnitsky, were tested at 3 ½−4 ½ years to identify effects of PAE. Although most children performed within the average range, Alcohol-Exposed preschoolers had lower scores on DAS-II Summary Scores as well as on specific subtests. To evaluate the effects of alcohol dose during the pre-pregnancy recognition period and during midgestation of pregnancy, generalized linear regression models were used controlling for demographic and individual variables. In addition to DAS-II variables, measures reflecting sustained attention, working memory and ability to shift cognitive set were impacted by alcohol dose. Early executive function appears to subsume these performance differences. In conclusion, findings indicate that the effects of PAE can be identified in the preschool period and reliably measured using tests assessing nonverbal and spatial skills supported by executive functioning.
登录
查看更多内容
影响因子：
3.6
作者：
Gillett, Raphael
通讯作者：
Gillett, Raphael
影响因子：
3.2
作者：
Chambers, Christina D.;Yevtushok, Lyubov;Wertelecki, Wladimir
通讯作者：
Wertelecki, Wladimir
影响因子：
56.9
作者：
MISCHEL, W;SHODA, Y;RODRIGUEZ, ML
通讯作者：
RODRIGUEZ, ML
影响因子：
14.6
作者：
Cook, Jocelynn L.;Green, Courtney R.;Rosales, Ted
通讯作者：
Rosales, Ted
影响因子：
2.3
作者：
Coles CD;Kable JA;Keen CL;Jones KL;Wertelecki W;Granovska IV;Pashtepa AO;Chambers CD;CIFASD
通讯作者：
CIFASD