Flavonoids, flavonoid subclasses and breast cancer risk: a meta-analysis of epidemiologic studies.
Flavonoids, flavonoid subclasses and breast cancer risk: a meta-analysis of epidemiologic studies.
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类黄酮、类黄酮亚类和乳腺癌风险：流行病学研究的荟萃分析。
DOI：
10.1371/journal.pone.0054318
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Mantian M
中科院分区：
文献类型：
--
作者：
Hui C;Qi X;Qianyong Z;Xiaoli P;Jundong Z;Mantian M
研究表明黄酮类化合物对癌的发生具有化学预防作用。然而，许多流行病学研究评估饮食类黄酮和乳腺癌的风险产生了不一致的结果。类黄酮、类黄酮亚类（黄酮醇、黄烷-3-醇等）患乳腺癌的风险缺乏系统分析。我们的目的是通过进行荟萃分析来检查类黄酮，每个类黄酮亚类（除了异黄酮）和乳腺癌风险之间的关联。我们使用科克伦图书馆、MEDLINE、EMBASE和PUBMED检索了2012年7月1日之前发表的前瞻性队列或病例对照研究设计的所有相关研究。使用固定或随机效应模型计算汇总相对风险（RR）。所有分析均使用STATA版本10.0进行。共纳入12项研究，涉及9 513例病例和181 906例对照，其中6项为前瞻性队列研究，6项为病例对照研究。我们分别计算了每个类黄酮亚类的最高和最低类别的乳腺癌风险的汇总RR。高黄酮醇类（RR = 0.88，95% CI：0.80-0.98）和黄酮类（RR = 0.83，95% CI：0.76-0.91）摄入者患乳腺癌的危险性显著低于低黄酮醇类和黄酮类摄入者。 然而，未观察到黄烷-3-醇（RR = 0.93，95%CI：0.84-1.02）、黄烷酮（汇总RR = 0.95，95%CI：0.88-1.03）、花青素（汇总RR = 0.97，95%CI：0.87-1.08）或总黄酮（汇总RR = 0.98，95%CI：0.86-1.12）摄入与乳腺癌风险的显著相关性。 此外，按绝经状态分层的3项病例对照研究的RR总结表明，黄酮醇、黄酮或黄烷-3-醇摄入与绝经后女性乳腺癌风险显著降低相关，而与绝经前女性无关。目前的研究表明，黄酮醇和黄酮的摄入量，而不是其他类黄酮亚类或总黄酮，与乳腺癌的风险降低有关，特别是在绝经后妇女中。
Studies have suggested the chemopreventive effects of flavonoids on carcinogenesis. Yet numbers of epidemiologic studies assessing dietary flavonoids and breast cancer risk have yielded inconsistent results. The association between flavonoids, flavonoid subclasses (flavonols, flavan-3-ols, etc.) and the risk of breast cancer lacks systematic analysis. We aimed to examine the association between flavonoids, each flavonoid subclass (except isoflavones) and the risk of breast cancer by conducting a meta-analysis. We searched for all relevant studies with a prospective cohort or case-control study design published before July 1st, 2012, using Cochrane library, MEDLINE, EMBASE and PUBMED. Summary relative risks (RR) were calculated using fixed- or random-effects models. All analyses were performed using STATA version 10.0. Twelve studies were included, involving 9 513 cases and 181 906 controls, six of which were prospective cohort studies, and six were case-control studies. We calculated the summary RRs of breast cancer risk for the highest vs lowest categories of each flavonoid subclass respectively. The risk of breast cancer significantly decreased in women with high intake of flavonols (RR = 0.88, 95% CI 0.80–0.98) and flavones (RR = 0.83, 95% CI: 0.76–0.91) compared with that in those with low intake of flavonols and flavones. However, no significant association of flavan-3-ols (RR = 0.93, 95% CI: 0.84–1.02), flavanones (summary RR = 0.95, 95% CI: 0.88–1.03), anthocyanins (summary RR = 0.97, 95% CI: 0.87–1.08) or total flavonoids (summary RR = 0.98, 95% CI: 0.86–1.12) intake with breast cancer risk was observed. Furthermore, summary RRs of 3 case-control studies stratified by menopausal status suggested flavonols, flavones or flavan-3-ols intake is associated with a significant reduced risk of breast cancer in post-menopausal while not in pre-menopausal women. The present study suggests the intake of flavonols and flavones, but not other flavonoid subclasses or total flavonoids, is associated with a decreased risk of breast cancer, especially among post-menopausal women.
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DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
7.1
作者：
Arts, ICW;Hollman, PCH
通讯作者：
Hollman, PCH
DOI：
10.1080/01635581.2012.717677
发表时间：
2012-01-01
影响因子：
2.9
作者：
Christensen, Krista Yorita;Naidu, Adonia;Koushik, Anita
通讯作者：
Koushik, Anita
影响因子：
5.2
作者：
Kim, Kyu Kwang;Singh, Ajay P.;Moore, Richard G.
通讯作者：
Moore, Richard G.
影响因子：
5
作者：
Fink, Brian N.;Steck, Susan E.;Gammon, Marilie D.
通讯作者：
Gammon, Marilie D.