Utility of Magnetic Resonance Spectroscopy for the Progression of Neurological Symptoms in Lenticulostriate Artery Territory Infarction.
Utility of Magnetic Resonance Spectroscopy for the Progression of Neurological Symptoms in Lenticulostriate Artery Territory Infarction.
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磁共振波谱检查在豆纹动脉区域梗塞神经症状进展中的应用。
DOI：
10.1016/j.jstrokecerebrovasdis.2021.105747
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Maruyama H.
中科院分区：
文献类型：
--
作者：
Shiga Y;Nezu T;Nakamori M;Hosomi N;Akiyama Y;Tachiyama K;Kamimura T;Kinoshita N;Hayashi Y;Matsushima H;Imamura E;Aoki S;Ueno H;Ohshita T;Wakabayashi S;Yamasaki F;Awai K;Maruyama H.
目的本研究旨在探讨质子磁共振波谱（1HMRS）在确定急性缺血性脑卒中患者的神经系统症状导致的进展的有效性，acutelostriate artery（LSA）infarct.Materials和Methods 1HMRS神经系统症状发作后72 h内进行。将感兴趣的体素放置在包括锥体束的组织中，并识别扩散加权回波平面自旋回波序列（DWI）冠状面图像。采用ABC/2法计算DWI的CT容积。采用LCModel对1HMRS数据（tNAA、tCr、Glx、tCho和Ins）进行分析。进行性神经系统症状定义为NIHSS评分增加1分或1分以上。排除了出现进展性神经系统症状后接受1HMRS的患者。结果共入组77例患者。其中，19例患者有进行性神经系统症状。有进行性神经系统症状的患者多为女性，且tCho/tCr值、DWI轴向切片≥ 3层的比例、DWI梗死体积、DWI轴向切片梗死最大直径、入院时SBP均高于无症状者。多变量Logistic回归分析显示，在校正年龄、性别和DWI梗死体积后，tCho/tCr值升高与神经系统症状进展独立相关（tCho/tCr每增加0.01，OR 1.26，95%CI 1.03- 1.52，P = 0.022）。1HMRS参数的定量评估可能有助于预测神经系统症状的进展。
ObjectivesThe present study aimed to examine the effectiveness of proton magnetic resonance spectroscopy (1HMRS) in determining the progression of neurological symptoms resulting in acute ischemic stroke in patients with lenticulostriate artery (LSA) infarction.Materials and Methods1HMRS was performed within 72 h after neurological symptom onset. Voxel of interest was placed in tissue that included the pyramidal tract and identified diffusion weighted echo planar spin-echo sequence (DWI) coronal images. Infarct volume in DWI was calculated using the ABC/2 method. 1HMRS data (tNAA, tCr, Glx, tCho, and Ins) were analyzed using LCModel. Progressive neurological symptoms were defined as an increase of 1 or more in the NIHSS score. Patients who underwent 1HMRS after progressive neurological symptoms were excluded.ResultsIn total, 77 patients were enrolled. Of these, 19 patients had progressive neurological symptoms. The patients with progressive neurological symptoms were significantly more likely to be female and had higher tCho/tCr values, higher rates of axial slices ≥ 3 slices on DWI, higher infarct volume on DWI, higher maximum diameter of infarction of axial slice on DWI, and higher SBP on admission compared to those without. Multivariable logistic analysis revealed that higher tCho/tCr values were independently associated with progressive neurological symptoms after adjusting for age, sex, and initial DWI infarct volume (tCho/tCr per 0.01 increase, OR 1.26, 95% CI 1.03–1.52,P= 0.022).ConclusionsIncreased tCho/tCr score were associated with progressive neurological symptoms in patients with LSA ischemic stroke. Quantitative evaluation of 1HMRS parameters may be useful for predicting the progression of neurological symptoms.
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影响因子：
3.3
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影响因子：
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