Staphylococcus aureus Panton-Valentine leukocidin targets muscle tissues in a child with myositis and necrotizing fasciitis.

Staphylococcus aureus Panton-Valentine leukocidin targets muscle tissues in a child with myositis and necrotizing fasciitis.
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金黄色葡萄球菌潘顿-瓦伦丁杀白细胞素针对患有肌炎和坏死性筋膜炎的儿童的肌肉组织。

DOI：
10.1086/649217
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发表时间：
2010
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
通讯作者：
Liu,GeorgeY
Liu,GeorgeY
中科院分区：
--
文献类型：
--
作者：
Lehman,Deborah;Tseng,ChingWen;Eells,Samantha;Miller,LorenG;Fan,Xuemo;Beenhouwer,DavidO;Liu,GeorgeY

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自从社区相关的耐甲氧西林金黄色葡萄球菌感染流行以来，肌炎的发病率一直在增加，而Panton-Valentine杀白细胞素被认为是导致更严重肌肉损伤的一个因素。我们报告一例严重肌炎并发脓毒性骨髓炎和坏死性筋膜炎所造成的潘顿-瓦伦丁杀白细胞素阳性。金色菌株免疫染色显示Panton-Valentine杀白细胞素毒素与坏死的肌肉组织有很强的结合。
The incidence of myositis has been increasing since the advent of the epidemic of community-associated methicillin-resistantStaphylococcus aureusinfection, and Panton-Valentine leukocidin has been implicated as a factor contributing to more-severe muscle injury. We report a case of severe myositis accompanying septic osteomyelitis and necrotizing fasciitis caused by a Panton-Valentine leukocidin-positiveS. aureusstrain. Immunostaining showed strong binding of the Panton-Valentine leukocidin toxin to necrotic muscle tissues.
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