Shared Inflammatory Pathology of Stroke and COVID-19.
Shared Inflammatory Pathology of Stroke and COVID-19.
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DOI：
10.3390/ijms23095150
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发表时间：
2022-05-05
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
虽然COVID-19的主要特征是外周症状，但它也可以影响中枢神经系统（CNS）。中风和COVID-19之间的关联已经证实了这一点。然而，导致与COVID-19感染相关的中风的分子机制尚未得到充分探索。更具体地说，中风和COVID-19表现出分子机制的重叠。这些相似之处为更好地理解COVID-19相关中风提供了一种方法。我们在此提出外周巨噬细胞上调炎症蛋白，如基质金属蛋白酶（MMPs），以应对SARS-CoV-2感染。这些炎症分子和SARS-CoV-2病毒具有多种与内皮功能障碍相关的负面影响，导致血脑屏障（BBB）被破坏。最后，我们讨论了内皮血脑屏障损伤如何通过导致星形胶质细胞功能障碍和炎性体激活来改变中枢神经系统功能。我们的目标是阐明这种炎症途径，从而为对抗COVID-19对神经系统的负面影响的治疗提供见解。
Though COVID-19 is primarily characterized by symptoms in the periphery, it can also affect the central nervous system (CNS). This has been established by the association between stroke and COVID-19. However, the molecular mechanisms that cause stroke related to a COVID-19 infection have not been fully explored. More specifically, stroke and COVID-19 exhibit an overlap of molecular mechanisms. These similarities provide a way to better understand COVID-19 related stroke. We propose here that peripheral macrophages upregulate inflammatory proteins such as matrix metalloproteinases (MMPs) in response to SARS-CoV-2 infection. These inflammatory molecules and the SARS-CoV-2 virus have multiple negative effects related to endothelial dysfunction that results in the disruption of the blood–brain barrier (BBB). Finally, we discuss how the endothelial blood–brain barrier injury alters central nervous system function by leading to astrocyte dysfunction and inflammasome activation. Our goal is to elucidate such inflammatory pathways, which could provide insight into therapies to combat the negative neurological effects of COVID-19.
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DOI：
10.1016/j.bbamcr.2014.11.012
发表时间：
2015-02
影响因子：
5.1
作者：
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通讯作者：
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影响因子：
2.6
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影响因子：
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影响因子：
3.3
作者：
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影响因子：
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作者：
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