MERS-CoV Antibody Responses 1 Year after Symptom Onset, South Korea, 2015.
MERS-CoV Antibody Responses 1 Year after Symptom Onset, South Korea, 2015.
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症状出现一年后的 MERS-CoV 抗体反应，韩国，2015 年。
DOI：
10.3201/eid2307.170310
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发表时间：
2017-07
影响因子：
11.8
通讯作者：
Oh MD
中科院分区：
文献类型：
--
作者：
Choe PG;Perera RAPM;Park WB;Song KH;Bang JH;Kim ES;Kim HB;Ko LWR;Park SW;Kim NJ;Lau EHY;Poon LLM;Peiris M;Oh MD
我们研究了中东呼吸综合征冠状病毒（MERS-CoV）中和和刺突蛋白抗体滴度在1年内的动力学，这些患者通过逆转录PCR证实在2015年韩国爆发期间感染。在所有患有严重疾病的幸存者中检测到稳健的抗体应答;在<1年的时间内，应答仍然可检测到，尽管有些减弱。痰液中病毒RNA检测持续时间（而非病毒载量）与抗体应答幅度显著相关。MERS S1 ELISA抗体滴度与中和抗体应答良好相关。6例轻度疾病患者中有4例的抗体滴度无法检测到，尽管大多数患者有肺炎的证据。这一发现意味着MERS-CoV血清流行病学研究明显低估了轻度和无症状感染的程度。获得具有高抗体滴度的恢复期血浆来治疗MERS将具有挑战性。
We investigated the kinetics of the Middle East respiratory syndrome coronavirus (MERS-CoV) neutralizing and spike protein antibody titers over the course of 1 year in 11 patients who were confirmed by reverse transcription PCR to have been infected during the outbreak in South Korea in 2015. Robust antibody responses were detected in all survivors who had severe disease; responses remained detectable, albeit with some waning, for <1 year. The duration of viral RNA detection (but not viral load) in sputum significantly correlated with the antibody response magnitude. The MERS S1 ELISA antibody titers correlated well with the neutralizing antibody response. Antibody titers in 4 of 6 patients who had mild illness were undetectable even though most had evidence of pneumonia. This finding implies that MERS-CoV seroepidemiologic studies markedly underestimate the extent of mild and asymptomatic infection. Obtaining convalescent-phase plasma with high antibody titers to treat MERS will be challenging.
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中东呼吸综合征冠状病毒感染的临床进展和细胞因子谱。
影响因子：
4.5
作者：
Kim ES;Choe PG;Park WB;Oh HS;Kim EJ;Nam EY;Na SH;Kim M;Song KH;Bang JH;Park SW;Kim HB;Kim NJ;Oh MD
通讯作者：
Oh MD
影响因子：
4.3
作者：
Korea Centers for Disease Control and Prevention
通讯作者：
Korea Centers for Disease Control and Prevention
影响因子：
11.8
作者：
Payne DC;Iblan I;Rha B;Alqasrawi S;Haddadin A;Al Nsour M;Alsanouri T;Ali SS;Harcourt J;Miao C;Tamin A;Gerber SI;Haynes LM;Al Abdallat MM
通讯作者：
Al Abdallat MM
影响因子：
11.8
作者：
Corman, Victor M.;Albarrak, Ali M.;Memish, Ziad A.
通讯作者：
Memish, Ziad A.
影响因子：
11.8
作者：
Alshukairi AN;Khalid I;Ahmed WA;Dada AM;Bayumi DT;Malic LS;Althawadi S;Ignacio K;Alsalmi HS;Al-Abdely HM;Wali GY;Qushmaq IA;Alraddadi BM;Perlman S
通讯作者：
Perlman S