Clinical Progression and Cytokine Profiles of Middle East Respiratory Syndrome Coronavirus Infection.
Clinical Progression and Cytokine Profiles of Middle East Respiratory Syndrome Coronavirus Infection.
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中东呼吸综合征冠状病毒感染的临床进展和细胞因子谱。
DOI：
10.3346/jkms.2016.31.11.1717
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发表时间：
2016-11
影响因子：
4.5
通讯作者：
Oh MD
中科院分区：
文献类型：
--
作者：
Kim ES;Choe PG;Park WB;Oh HS;Kim EJ;Nam EY;Na SH;Kim M;Song KH;Bang JH;Park SW;Kim HB;Kim NJ;Oh MD
在中东呼吸综合征冠状病毒（MERS-CoV）感染患者中，随着时间推移的临床进展和细胞因子谱尚未得到很好的定义。我们纳入了2015年韩国爆发期间实验室确认的MERS-CoV患者。前瞻性收集临床和实验室参数。采用酶联免疫吸附法测定血清细胞因子和趋化因子水平。所有患者均出现发热。中位退热时间为18天。9例患者需要补充氧气，并被归类为重度组。在重症组中，胸部浸润在发病第7天左右突然开始恶化，第一周末出现呼吸困难，第二周变得明显。从症状发作到补充氧气的中位时间为8天。重度组第1周的中性粒细胞计数高于轻度组（4，500 vs. 2，200/µL，P = 0.026）。在发病的第二周，重症组的血清IL-6（54 vs.4pg/mL，P = 0.006）和CXCL-10（2，642 vs.382 pg/mL，P < 0.001）水平较高。在轻度病例中未观察到IFN-α反应。我们的数据显示，临床状况可能在发病7天左右突然恶化，并且在发展为严重疾病的MERS-CoV患者中，IL-6和CXCL-10的血清水平显著升高。
Clinical progression over time and cytokine profiles have not been well defined in patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection. We included 17 patients with laboratory-confirmed MERS-CoV during the 2015 outbreak in Korea. Clinical and laboratory parameters were collected prospectively. Serum cytokine and chemokine levels in serial serum samples were measured using enzyme-linked immunosorbent assay. All patients presented with fever. The median time to defervescence was 18 days. Nine patients required oxygen supplementation and classified into severe group. In the severe group, chest infiltrates suddenly began to worsen around day 7 of illness, and dyspnea developed at the end of the first week and became apparent in the second week. Median time from symptom onset to oxygen supplementation was 8 days. The severe group had higher neutrophil counts during week 1 than the mild group (4,500 vs. 2,200/µL, P = 0.026). In the second week of illness, the severe group had higher serum levels of IL-6 (54 vs. 4 pg/mL, P = 0.006) and CXCL-10 (2,642 vs. 382 pg/mL, P < 0.001). IFN-α response was not observed in mild cases. Our data shows that clinical condition may suddenly deteriorate around 7 days of illness and the serum levels of IL-6 and CXCL-10 was significantly elevated in MERS-CoV patients who developed severe diseases.
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影响因子：
4.5
作者：
Oh, Myoung-don;Choe, Pyoeng Gyun;Kim, Nam Joong
通讯作者：
Kim, Nam Joong
影响因子：
6.4
作者：
Chi, Ying;Zhu, Yefei;Zhou, Minghao
通讯作者：
Zhou, Minghao
影响因子：
4.3
作者：
Korea Centers for Disease Control and Prevention
通讯作者：
Korea Centers for Disease Control and Prevention
DOI：
10.1016/j.ijid.2014.09.003
发表时间：
2014-12
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
--
作者：
Saad M;Omrani AS;Baig K;Bahloul A;Elzein F;Matin MA;Selim MA;Al Mutairi M;Al Nakhli D;Al Aidaroos AY;Al Sherbeeni N;Al-Khashan HI;Memish ZA;Albarrak AM
通讯作者：
Albarrak AM
DOI：
10.1056/nejmoa1306742
发表时间：
2013-08-01
期刊：
The New England journal of medicine
影响因子：
--
作者：
Assiri A;McGeer A;Perl TM;Price CS;Al Rabeeah AA;Cummings DA;Alabdullatif ZN;Assad M;Almulhim A;Makhdoom H;Madani H;Alhakeem R;Al-Tawfiq JA;Cotten M;Watson SJ;Kellam P;Zumla AI;Memish ZA;KSA MERS-CoV Investigation Team
通讯作者：
KSA MERS-CoV Investigation Team