Impact of Rehabilitation on Breast Cancer Related Fatigue: A Pilot Study.
Impact of Rehabilitation on Breast Cancer Related Fatigue: A Pilot Study.
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康复对乳腺癌相关疲劳的影响：一项试点研究。
DOI：
10.3389/fonc.2020.556718
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发表时间：
2020
影响因子：
4.7
通讯作者：
Fusco N
中科院分区：
文献类型：
--
作者：
Invernizzi M;de Sire A;Lippi L;Venetis K;Sajjadi E;Gimigliano F;Gennari A;Criscitiello C;Cisari C;Fusco N
乳腺癌疲劳（BCF）是一种复杂和多方面的疾病，其特征是持续的身体和/或精神僵硬感，导致乳腺癌幸存者健康相关生活质量的严重损害。这项前瞻性队列研究的目的是评估为期4周的康复方案对乳腺癌（BC）幸存者的BCF、肌肉质量、力量、体能和生活质量的可行性和有效性。我们招募了成年BC妇女诊断为BCF，根据国际疾病分类10标准，转介到一所大学医院的肿瘤康复门诊服务。所有参与者进行了一个特定的体育锻炼康复方案，包括60分钟的会议，每周重复2次，持续4周。在基线（T0）、4周康复治疗结束时（T1）和2个月随访时（T2）评价所有结局。主要结局指标为简明疲劳量表（BFI）;次要结局包括：通过生物电阻抗分析（BIA）评估的去脂质量和脂肪质量;手部握力测试（HGS）;短体力功能成套测试（SPPB）; 10米步行试验（10 MWT）; 6分钟步行试验（6 MWT）;欧洲癌症研究和治疗组织生活质量问卷（EORTC QLQ-C30）。36名女性（平均年龄：55.17 ± 7.76岁）入组研究。在4周康复治疗后（T1）（BFI：5.4 ± 1.6 vs. 4.2 ± 1.7; p = 0.004）和随访访视时（T2）（BFI：5.4 ± 1.6 vs. 4.4 ± 1.6; p = 0.004）均观察到BCF显著降低。此外，T1时HGS、SPPB、10 MWT、6 MWT和EORTC QLQ-C30与基线相比存在显著差异（p < 0.001），而T2时所有结局指标与基线相比均存在显著差异（p < 0.05）。康复方案似乎是可行的，安全的，有效地减少BCF，改善肌肉质量和功能，并改善HRQoL在一个队列的BC幸存者。本研究的结果可以提高人们对这种被低估的疾病的认识，建议定义特定的治疗性运动方案来降低BCF。
Breast cancer fatigue (BCF) is a complex and multidimensional condition characterized by a persistent sense of physical and/or mental stiffness, resulting in a substantial impairment of health-related quality of life in breast cancer survivors. Aim of this prospective cohort study was to evaluate the feasibility and the effectiveness of a 4-week rehabilitation protocol on BCF, muscle mass, strength, physical performance, and quality of life in breast cancer (BC) survivors. We recruited adult BC women with a diagnosis of BCF, according to the International Classification of Diseases 10 criteria, referred to the Outpatient Service for Oncological Rehabilitation of a University Hospital. All participants performed a specific physical exercise rehabilitative protocol consisting of 60-min sessions repeated 2 times/week for 4 weeks. All outcomes were evaluated at the baseline (T0), at the end of the 4-week rehabilitation treatment (T1), and at 2 months follow up (T2). The primary outcome measure was the Brief Fatigue Inventory (BFI); secondary outcomes included: Fat-Free Mass and Fat Mass, assessed by Bioelectrical Impedance Analysis (BIA); Hand Grip Strength Test (HGS); Short Physical Performance Battery (SPPB); 10-meter walking test (10 MWT); 6-min walking test (6 MWT); European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ–C30). Thirty-six women (mean age: 55.17 ± 7.76 years) were enrolled in the study. Significant reduction of BCF was observed both after the 4-week rehabilitation treatment (T1) (BFI: 5.4 ± 1.6 vs. 4.2 ± 1.7; p = 0.004) and at the follow-up visit (T2) (BFI: 5.4 ± 1.6 vs. 4.4 ± 1.6; p = 0.004). Moreover, significant differences (p < 0.001) HGS, SPPB, 10 MWT, 6 MWT, and EORTC QLQ-C30 were found at T1, while at T2 all the outcome measures were significantly different (p < 0.05) from the baseline. The rehabilitation protocol seemed to be feasible, safe, and effective in reducing BCF, improving muscle mass and function, and improving HRQoL in a cohort of BC survivors. The results of this study could improve awareness of this underestimated disease, suggesting the definition of a specific therapeutic exercise protocol to reduce BCF.
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影响因子：
8.9
作者：
Dirks-Naylor, Amie J.;Tran, Ngan T. K.;Yang, Sendra;Mabolo, Raean;Kouzi, Samir A.
通讯作者：
Kouzi, Samir A.
DOI：
10.1007/s00432-019-02996-y
发表时间：
2019-10-01
影响因子：
3.6
作者：
Alizadeh, Ali Mohammad;Isanejad, Amin;Hassan, Zuhair Mohammad
通讯作者：
Hassan, Zuhair Mohammad
影响因子：
3.8
作者：
Brown, Justin C.;Huedo-Medina, Tania B.;Johnson, Blair T.
通讯作者：
Johnson, Blair T.
影响因子：
120.7
作者：
Holmes, MD;Chen, WY;Colditz, GA
通讯作者：
Colditz, GA
淋巴血管侵袭和肿瘤外肿瘤扩展是乳腺癌相关的淋巴水肿的风险指标：一项长期随访的观察性回顾性研究。
影响因子：
3.8
作者：
Invernizzi M;Corti C;Lopez G;Michelotti A;Despini L;Gambini D;Lorenzini D;Guerini-Rocco E;Maggi S;Noale M;Fusco N
通讯作者：
Fusco N