Lipid body formation plays a central role in cell fate determination during developmental differentiation of Myxococcus xanthus.
Lipid body formation plays a central role in cell fate determination during developmental differentiation of Myxococcus xanthus.
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脂质体的形成在粘液菌的发育分化过程中在细胞命运测定中起着核心作用。
DOI：
10.1111/j.1365-2958.2009.06879.x
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发表时间：
2009-10
影响因子：
3.6
通讯作者：
Bode, Helge B.
中科院分区：
文献类型：
--
作者：
Hoiczyk, Egbert;Ring, Michael W.;McHugh, Colleen A.;Schwaer, Gertrud;Bode, Edna;Krug, Daniel;Altmeyer, Matthias O.;Lu, Jeff Zhiqiang;Bode, Helge B.
细胞分化在多细胞生物体的发育过程中广泛存在，但在原核生物中很少观察到。原核生物分化的一个例子是革兰氏阴性细菌黄色粘球菌。作为对饥饿的反应，这种滑行的细菌启动了一个复杂的发育程序，导致形成充满孢子的子实体。细胞如何在代谢上支持从杆状营养细胞到球形孢子的必要的复杂细胞分化尚不清楚。在这里，我们提出了细胞内脂体为孢子发育提供必要的代谢燃料的证据。这些脂体在饥饿开始时形成，逐渐消失，直到细胞成为成熟孢子时完全用完。此外，黄花中脂体的形成似乎是指示细胞在分化过程中命运的重要初始步骤。饥饿时，会出现两种亚群的细胞：形成脂体的细胞总是发育成孢子，而不形成脂体的细胞最终会变成外周杆状细胞，即缺乏形态分化迹象并停留在类植物状态的细胞。这些数据表明，脂体不仅促进细胞分化，而且它们的形成是第一个已知的表明细胞在分化过程中命运的形态标志。
Cell differentiation is widespread during the development of multicellular organisms, but rarely observed in prokaryotes. One example of prokaryotic differentiation is the Gramnegative bacterium Myxococcus xanthus. In response to starvation, this gliding bacterium initiates a complex developmental program that results in the formation of spore-filled fruiting bodies. How the cells metabolically support the necessary complex cellular differentiation from rod-shaped vegetative cells into spherical spores is unknown. Here, we present evidence that intra-cellular lipid bodies provide the necessary metabolic fuel for the development of spores. Formed at the onset of starvation, these lipid bodies gradually disappear until they are completely used up by the time the cells have become mature spores. Moreover, it appears that lipid body formation in M. xanthus is an important initial step indicating cell fate during differentiation. Upon starvation, two subpopulations of cells occur: cells that form lipid bodies invariably develop into spores, while cells that do not form lipid bodies end up becoming peripheral rods, which are cells that lack signs of morphological differentiation and stay in a vegetative-like state. These data indicate that lipid bodies not only fuel cellular differentiation but that their formation represents the first known morphological sign indicating cell fate during differentiation.
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影响因子：
2.7
作者：
HAGEN, DC;BRETSCHER, AP;KAISER, D
通讯作者：
KAISER, D
DOI：
10.1016/s1044-0305(99)00035-5
发表时间：
1999-07-01
影响因子：
3.2
作者：
Hsu, FF;Turk, J
通讯作者：
Turk, J
影响因子：
56.9
作者：
Gonzalez-Pastor, JE;Hobbs, EC;Losick, R
通讯作者：
Losick, R
影响因子：
10.5
作者：
KROOS, L;KAISER, D
通讯作者：
KAISER, D
影响因子：
3.2
作者：
Bode, Helge B.;Ring, Michael W.;Mueller, Rolf
通讯作者：
Mueller, Rolf