Spectral domain optical coherence tomography for quantitative evaluation of drusen and associated structural changes in non-neovascular age-related macular degeneration.
Spectral domain optical coherence tomography for quantitative evaluation of drusen and associated structural changes in non-neovascular age-related macular degeneration.
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DOI：
10.1136/bjo.2008.137356
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发表时间：
2009-02
期刊：
影响因子：
--
通讯作者：
Chen TC
中科院分区：
文献类型：
--
作者：
Yi K;Mujat M;Park BH;Sun W;Miller JW;Seddon JM;Young LH;de Boer JF;Chen TC
为了证明与时域光学相干断层扫描（TDOCT）相比，光谱域光学相干断层扫描（SDOCT）可以更好地评估非新生血管性年龄相关性黄斑变性（AMD）患者的眼部病变和相关解剖变化。使用实验性SDOCT系统对3例AMD患者的3只眼进行图像采集。使用钛蓝宝石（Ti：蓝宝石）激光器和超发光二极管（SLD）作为宽带光源来实现视网膜的横截面图像。对与非新生血管性AMD相关的结构改变进行定性和定量分析。开发了一种自动算法来分析SDOCT图像的鼓泡面积和体积。TDOCT采用快速黄斑扫描（StratusOCT, Carl Zeiss Meditec, Dublin, California）。SDOCT图像可以显示与非新生血管性AMD相关的结构改变。提出了一种新的SDOCT算法，可以确定鼓泡面积、鼓泡体积和鼓泡比例。SDOCT具有确定结节面积和体积的新算法，以及前所未有的同时超高速超高分辨率成像，可以提高对非新生血管性AMD结构异常的评估。
To demonstrate how spectral domain optical coherence tomography (SDOCT) can better evaluate drusen and associated anatomical changes in eyes with non-neovascular age-related macular degeneration (AMD) compared with time domain optical coherence tomography (TDOCT). Images were obtained from three eyes of three patients with AMD using an experimental SDOCT system. Both a titanium–sapphire (Ti:sapphire) laser and a superluminescent diode (SLD) were used as a broadband light source to achieve cross-sectional images of the retina. A qualitative and quantitative analysis was performed for structural changes associated with non-neovascular AMD. An automated algorithm was developed to analyse drusen area and volume from SDOCT images. TDOCT was performed using the fast macular scan (StratusOCT, Carl Zeiss Meditec, Dublin, California). SDOCT images can demonstrate structural changes associated with non-neovascular AMD. A new SDOCT algorithm can determine drusen area, drusen volume and proportion of drusen. With new algorithms to determine drusen area and volume and its unprecedented simultaneous ultra-high speed ultra-high resolution imaging, SDOCT can improve the evaluation of structural abnormalities in non-neovascular AMD.
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影响因子：
--
作者：
Kassoff, A;Kassoff, J;Chew, EY
通讯作者：
Chew, EY
影响因子：
13.7
作者：
Wojtkowski, M;Srinivasan, V;Duker, JS
通讯作者：
Duker, JS
影响因子：
3.6
作者：
Leitgeb, RA;Hitzenberger, CK;Bajraszewski, T
通讯作者：
Bajraszewski, T
影响因子：
13.7
作者：
Klein, Ronald;Klein, Barbara E. K.;Gangnon, Ronald E.
通讯作者：
Gangnon, Ronald E.
影响因子：
4.2
作者：
Chen, TC;Cense, B;de Boer, JF
通讯作者：
de Boer, JF