Angular Gyrus Involvement at Encoding and Retrieval Is Associated with Durable But Less Specific Memories
Angular Gyrus Involvement at Encoding and Retrieval Is Associated with Durable But Less Specific Memories
复制标题
角回参与编码和检索与持久但不太具体的记忆相关
作者：
Mieke van der Linden;R. Berkers;R. Morris;G. Fernández
合并后，属于心理图式的信息会被更好地记住，但当涉及到细节时，这种记忆可能不那么具体。与这种行为模式一致的神经元机制可能是一种动态相互作用的结果，这种相互作用需要特定的皮质网络与相关的海马区分离。我们现在报道，在男性和女性成年受试者中，对嵌入语义图式中的一系列对象进行编码和后来的巩固与角回(AG)中预测24小时后记忆的活动的积聚有关。同时，随着图式对象的连续编码，后部海马区的参与变得更少。海马区的脱离与错误记忆编码时没有呈现的物体的增加有关。在编码和提取过程中，AG和外侧枕叶复合体(LOC)在功能上相互连接，这种相互作用有利于成功的提取。因此，包括AG和LOC的网络增强了与图式相关的记忆的夜间保持，而它们同时从海马区分离降低了记忆的特异性。重要性陈述这项研究提供了第一个经验证据，说明当获得并有效保留与先前存在的知识相关的持久知识时，海马体和新皮质如何动态地相互作用，但这是以记忆专一性为代价的。这种相互作用是一种基本的助记操作，到目前为止，在记忆研究中基本上被忽视了。
After consolidation, information belonging to a mental schema is better remembered, but such memory can be less specific when it comes to details. A neuronal mechanism consistent with this behavioral pattern could result from a dynamic interaction that entails mediation by a specific cortical network with associated hippocampal disengagement. We now report that, in male and female adult human subjects, encoding and later consolidation of a series of objects embedded in a semantic schema was associated with a buildup of activity in the angular gyrus (AG) that predicted memory 24 h later. In parallel, the posterior hippocampus became less involved as schema objects were encoded successively. Hippocampal disengagement was related to an increase in falsely remembering objects that were not presented at encoding. During both encoding and retrieval, the AG and lateral occipital complex (LOC) became functionally connected and this interaction was beneficial for successful retrieval. Therefore, a network including the AG and LOC enhances the overnight retention of schema-related memories and their simultaneous detachment from the hippocampus reduces the specificity of the memory. SIGNIFICANCE STATEMENT This study provides the first empirical evidence on how the hippocampus and the neocortex interact dynamically when acquiring and then effectively retaining durable knowledge that is associated to preexisting knowledge, but they do so at the cost of memory specificity. This interaction is a fundamental mnemonic operation that has thus far been largely overlooked in memory research.
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影响因子：
3.7
作者：
Fernandino, Leonardo;Binder, Jeffrey R.;Seidenberg, Mark S.
通讯作者：
Seidenberg, Mark S.
DOI：
10.1073/pnas.92.18.8135
发表时间：
1995-08-29
影响因子：
11.1
作者：
MALACH, R;REPPAS, JB;TOOTELL, RBH
通讯作者：
TOOTELL, RBH
DOI：
--
发表时间：
2008
期刊：
--
影响因子：
--
作者：
Kaori Takehara-Nishiuchi;B. McNaughton
通讯作者：
Kaori Takehara-Nishiuchi;B. McNaughton
影响因子：
22.4
作者：
Danker, Jared F.;Anderson, John R.
通讯作者：
Anderson, John R.
DOI：
10.1073/pnas.0507774103
发表时间：
2006-01-17
影响因子：
11.1
作者：
Takashima, A;Petersson, KM;Fernández, G
通讯作者：
Fernández, G