Non-human primate FOG develops with advanced parkinsonism induced by MPTP Treatment.
Non-human primate FOG develops with advanced parkinsonism induced by MPTP Treatment.
复制标题
DOI：
10.1016/j.expneurol.2012.07.021
复制
发表时间：
2012-10
影响因子：
5.3
通讯作者：
Papa SM
中科院分区：
文献类型：
--
作者：
Revuelta GJ;Uthayathas S;Wahlquist AE;Factor SA;Papa SM
步态冻结（FOG）是帕金森病（PD）和其他形式的帕金森综合征的一个衰弱特征。解剖学或病理生理学相关性知之甚少，主要是由于缺乏一个完善的动物模型。在这里，我们研究了FOG是否在PD的非人灵长类动物（NHP）模型中再现。用1-甲基-4-苯基-1，2，3，6-四氢吡啶（MPTP）处理猕猴（Macaca属，n=29），观察FOG的形成，并用加速度计记录下肢运动。确定了FOG发展与动物特征、MPTP治疗和建模结果之间的关系。在帕金森病猴中，FOG经常发生（48%），表现出与PD患者相似的特征。此外，猴的FOG发作伴有典型持续时间（2-10 s）和频率（~7 Hz）的腿颤。NHP FOG的发生与帕金森综合征的严重程度显著相关，如高运动残疾评分（≥20）和左旋多巴诱导的运动障碍评分（分别为p=0.01和p=0.04）所示。人口统计学和MPTP治疗（剂量、治疗持续时间等）的差异对NHP FOG的发生没有影响，除了性别显示FOG在男性中占优势（p=0.03）。PD中FOG的独特特征可以在严重帕金森病猕猴中复制，这代表了FOG动物模型的首次描述。
Freezing of gait (FOG) is a debilitating feature of Parkinson’s disease (PD) and other forms of parkinsonism. The anatomical or pathophysiological correlates are poorly understood largely due to the lack of a well-established animal model. Here we studied whether FOG is reproduced in the non-human primate (NHP) model of PD. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys (Genus Macaca, n=29) were examined for the development of FOG, and the leg movements were recorded with accelerometry. The relationships between developing FOG and the animals’ characteristics, the MPTP treatments, and the modeled outcomes were determined. In parkinsonian monkeys FOG developed frequently (48%) manifesting similar characteristics to those seen in PD patients. In addition, FOG episodes in the monkey were accompanied by leg trembling with the typical duration (2–10 s) and frequency (~7 Hz). The development of NHP FOG was significantly associated with the severity of parkinsonism, as shown by high motor disability scores (≥20) and levodopa-induced dyskinesia scores (p=0.01 and p=0.04, respectively). Differences in demographics and MPTP treatments (doses, treatment duration, etc.) had no influence on NHP FOG occurrence, with the exception of gender that showed FOG predominance in males (p=0.03). The unique features of FOG in PD can be replicated in severely parkinsonian macaques, and this represents the first description of a FOG animal model.
登录
查看更多内容
影响因子：
3.3
作者：
MAVRIDIS, M;DEGRYSE, AD;COLPAERT, FC
通讯作者：
COLPAERT, FC
影响因子：
15.9
作者：
Karachi, Carine;Grabli, David;Francois, Chantal
通讯作者：
Francois, Chantal
影响因子：
1.1
作者：
Pereira, E A;Muthusamy, K A;Aziz, T Z
通讯作者：
Aziz, T Z
影响因子：
8.6
作者：
Macht, Michael;Kaussner, Yvonne;Ellgring, Heiner
通讯作者：
Ellgring, Heiner
影响因子：
158.5
作者：
Rascol, O;Brooks, DJ;Lang, AE
通讯作者：
Lang, AE