Comparison of brown and white adipose tissues in infants and children with chemical-shift-encoded water-fat MRI.
Comparison of brown and white adipose tissues in infants and children with chemical-shift-encoded water-fat MRI.
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DOI：
10.1002/jmri.24053
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发表时间：
2013-10
影响因子：
4.4
通讯作者：
Gilsanz, Vicente
中科院分区：
文献类型：
--
作者：
Hu, Houchun H.;Yin, Larry;Aggabao, Patricia C.;Perkins, Thomas G.;Chia, Jonathan M.;Gilsanz, Vicente
关键词：
比较位于锁骨上窝和皮下的棕色(BAT)和白色(WAT)脂肪组织的脂肪信号分数(FF)和T2*值。研究对象为12名婴儿和39名儿童。儿童被分为瘦子组和超重/肥胖组。使用化学位移编码的水脂肪磁共振成像来量化锁骨上和邻近皮下脂肪组织库中的FF和T2*指标。进行线性回归和t检验。婴儿锁骨上FF低于儿童(p<；0.01)，但T2*值相似(p=0.5)。瘦儿童的锁骨上FFS和T2*值低于超重儿童(p<；0.01)。在每个单独的婴儿和儿童中，锁骨上的FF始终低于相邻的皮下FF。儿童锁骨上T2*值始终低于皮下T2*值，但婴儿则不是。两个仓库的FFS与婴儿的年龄和体重呈正相关(p<；0.01)。在儿童中，它们与体重和BMI相关(p<；0.01)，但与年龄无关。T2*与人体测量变量的相关性在儿童中存在(p<；0.01)，但在婴儿中不存在。横断面比较表明，婴儿和儿童锁骨上和皮下脂肪储备的FF值和T2*值存在差异，这可能表明脂肪组织脂肪含量、数量和代谢活动的生理差异。
To compare fat-signal fractions (FFs) and T2* values between brown (BAT) and white (WAT) adipose tissue located within the supraclavicular fossa and subcutaneous depots, respectively. Twelve infants and 39 children were studied. Children were divided into lean and overweight/obese sub-groups. Chemical-shift-encoded water-fat MRI was used to quantify FFs and T2* metrics in the supraclavicular and adjacent subcutaneous adipose tissue depots. Linear regression and t-tests were performed. Infants had lower supraclavicular FFs than children (p<0.01) but T2* values were similar (p=0.5). Lean children exhibited lower supraclavicular FFs and T2* values than overweight children (p<0.01). In each individual infant and child, supraclavicular FFs were consistently lower than adjacent subcutaneous FFs. Supraclavicular T2* values were consistently lower than subcutaneous T2* values in children, but not in infants. FFs in both depots were positively correlated with age and weight in infants (p<0.01). In children, they were correlated with weight and BMI (p<0.01), but not age. Correlations between T2* and anthropometric variables existed in children (p<0.01), but were absent in infants. Cross-sectional comparisons suggest variations in FF and T2* values in the supraclavicular and subcutaneous depots of infants and children, which are potentially indicative of physiological differences in adipose tissue fat content, amount, and metabolic activity.
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影响因子：
3.3
作者：
Branca RT;Warren WS
通讯作者：
Warren WS
DOI：
10.1126/science.1190816
发表时间：
2010-05-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Ishibashi J;Seale P
通讯作者：
Seale P
影响因子：
4.4
作者：
Hines, Catherine D. G.;Agni, Rashmi;Roen, Calista;Rowland, Ian;Hernando, Diego;Bultman, Eric;Horng, Debra;Yu, Huanzhou;Shimakawa, Ann;Brittain, Jean H.;Reeder, Scott B.
通讯作者：
Reeder, Scott B.
影响因子：
3.6
作者：
Gilsanz, Vicente;Hu, Houchun H.;Kajimura, Shingo
通讯作者：
Kajimura, Shingo
影响因子：
4.4
作者：
Horng, Debra E.;Hernando, Diego;Hines, Catherine D. G.;Reeder, Scott B.
通讯作者：
Reeder, Scott B.