Relevance of brown adipose tissue in infancy and adolescence.
Relevance of brown adipose tissue in infancy and adolescence.
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DOI：
10.1038/pr.2012.141
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发表时间：
2013-01
影响因子：
3.6
通讯作者：
Kajimura, Shingo
中科院分区：
文献类型：
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作者：
Gilsanz, Vicente;Hu, Houchun H.;Kajimura, Shingo
棕色脂肪组织(BAT)被认为在婴儿期后消失。最近在接受正电子发射断层扫描/计算机断层扫描(PET/CT)的患者中发现BAT的研究重新引起了人们对破译这一组织与人类的相关性的兴趣。现有数据表明，BAT在儿童中比在成年人中更普遍，而且它在青春期的激活与体重和肥胖症的增加明显减少有关。数据还显示，在PET/CT检查中有代谢活跃的BAT的儿科患者比没有BAT的患者有更大的肌肉体积。在青春期，蝙蝠的活动和数量都会增加。与女孩相比，男孩的增加幅度更大，并且与肌肉体积的增加密切相关。因此，在婴儿期和青春期骨骼肌获得巨大增长的同时，所有婴儿和青少年都积累了大量的蝙蝠。这些观察结果与体外研究结果一致，表明棕色脂肪细胞、白色脂肪细胞和肌小体之间存在密切的相互作用。在这篇综述中，我们讨论了这种组织在调节儿童体重和肌肉骨骼发育方面的潜在作用。
Brown adipose tissue (BAT) was thought to disappear after infancy. Recent studies finding BAT in patients undergoing positron emission tomography/computed tomography (PET/CT) have renewed the interest in deciphering the relevance of this tissue in humans. Available data suggests that BAT is more prevalent in children than in adults, and that its activation during adolescence is associated to significantly less gains in weight and adiposity. Data also shows that pediatric patients with metabolically-active BAT on PET/CT examinations have significantly greater muscle volume than patients with no identifiable BAT. Both the activity and the amount of BAT increase during puberty. The magnitude of the increase is higher in boys when compared to girls, and closely related to gains in muscle volume. Hence, concurrent with the great gains in skeletal muscle during infancy and puberty, all infants and adolescents accumulate large amounts of BAT. These observations are consistent with in vitro investigations suggesting close interactions between brown adipocytes, white adipocytes, and myocites. In this review, we discuss the potential role of this tissue in regulating weight and musculoskeletal development in children.
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影响因子：
5.1
作者：
Gilsanz, Vicente;Smith, Michelle L.;Goodarzian, Fariba;Kim, Mimi;Wren, Tishya A. L.;Hu, Houchun H.
通讯作者：
Hu, Houchun H.
影响因子：
3.1
作者：
Garcia, CA;Van Nostrand, D;Majd, M
通讯作者：
Majd, M
影响因子：
7.1
作者：
Chalfant, James S.;Smith, Michelle L.;Gilsanz, Vicente
通讯作者：
Gilsanz, Vicente
影响因子：
4.8
作者：
Hamann, A;Flier, JS;Lowell, BB
通讯作者：
Lowell, BB
影响因子：
64.8
作者：
通讯作者：
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