Kinked p-n junction nanowire probes for high spatial resolution sensing and intracellular recording.
Kinked p-n junction nanowire probes for high spatial resolution sensing and intracellular recording.
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DOI：
10.1021/nl300256r
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发表时间：
2012-03-14
期刊：
影响因子：
10.8
通讯作者：
Lieber CM
中科院分区：
文献类型：
--
作者：
Jiang Z;Qing Q;Xie P;Gao R;Lieber CM
半导体纳米线和配置为场效应晶体管的其他半导体纳米级材料已经作为生物/化学（bio/chem.）传感器.这些纳米材料已经证明了一维和二维传感器的高灵敏度，尽管最终点状探测器的实现还没有实现。在这方面，纳米级p-n二极管是有吸引力的，因为器件元件自然地位于结附近，并且虽然纳米线p-n二极管已经作为光伏器件被广泛研究，但是它们作为生物/化学传感器的应用尚未被探索。在这里，我们表明，p-n二极管器件可以作为一个新的和强大的家庭高度本地化的生物传感器探针。在弯折的硅纳米线的连接处综合引入了设计的纳米尺度轴向p-n结。扫描电子显微镜图像显示，实现了扭结的纳米线结构，和电输运测量表现出整流行为与良好定义的导通正向偏置预期的p-n二极管。此外，扫描门显微镜表明，这些纳米线的最敏感的区域是本地化附近的p-n结的扭结区域。使用这些p-n二极管探针的高空间分辨率传感在水溶液中使用荧光带电聚苯乙烯纳米珠进行。多重电测量显示了明确的单纳米颗粒检测，同时共聚焦成像的实验直接关联的运动的nanobeads从p-n设备记录的电信号。此外，扭结的p-n结纳米线配置为三维探针证明了从生电细胞的动作电位的细胞内记录的能力。这些p-n结扭结纳米线器件代表了一种构建具有高度局部化传感区域的纳米级探针的新方法，在从生物/化学传感和纳米级光子检测到活细胞和组织内的三维记录等领域提供了大量机会。
Semiconductor nanowires and other semiconducting nanoscale materials configured as field-effect transistors have been studied extensively as biological/chemical (bio/chem.) sensors. These nanomaterials have demonstrated high-sensitivity from one- and two-dimensional sensors, although the realization of the ultimate point-like detector has not been achieved. In this regard, nanoscale p-n diodes are attractive since the device element is naturally localized near the junction, and while nanowire p-n diodes have been widely studied as photovoltaic devices, their applications as bio/chem. sensors have not been explored. Here we demonstrate that p-n diode devices can serve as a new and powerful family of highly localized biosensor probes. Designed nanoscale axial p-n junctions were synthetically introduced at the joints of kinked silicon nanowires. Scanning electron microscopy images showed that the kinked nanowire structures were achieved, and electrical transport measurements exhibited rectifying behavior with well-defined turn-on in forward bias as expected for a p-n diode. In addition, scanning gate microscopy demonstrated that the most sensitive region of these nanowires was localized near the kinked region at the p-n junction. High spatial resolution sensing using these p-n diode probes was carried out in aqueous solution using fluorescent charged polystyrene nanobeads. Multiplexed electrical measurements show well-defined single-nanoparticle detection, and experiments with simultaneous confocal imaging correlate directly the motion of the nanobeads with the electrical signals recorded from the p-n devices. In addition, kinked p-n junction nanowires configured as three-dimensional probes demonstrate the capability of intracellular recording of action potentials from electrogenic cells. These p-n junction kinked nanowire devices, which represent a new way of constructing nanoscale probes with highly-localized sensing regions, provide substantial opportunity in areas ranging from bio/chem. sensing and nanoscale photon detection to three-dimensional recording from within living cells and tissue.
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影响因子：
64.8
作者：
Tian, Bozhi;Zheng, Xiaolin;Lieber, Charles M.
通讯作者：
Lieber, Charles M.
影响因子：
38.3
作者：
Xu, Sheng;Qin, Yong;Wang, Zhong Lin
通讯作者：
Wang, Zhong Lin
影响因子：
10.8
作者：
Cohen-Karni T;Qing Q;Li Q;Fang Y;Lieber CM
通讯作者：
Lieber CM
影响因子：
13.3
作者：
Heller, Iddo;Smaal, Wiljan T. T.;Dekker, Cees
通讯作者：
Dekker, Cees
影响因子：
64.8
作者：
Stern, Eric;Klemic, James F.;Reed, Mark A.
通讯作者：
Reed, Mark A.