Polyester vascular patches acquire arterial or venous identity depending on their environment.
Polyester vascular patches acquire arterial or venous identity depending on their environment.
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DOI：
10.1002/jbm.a.36193
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发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
Dardik A
中科院分区：
文献类型：
--
作者：
Bai H;Hu H;Guo J;Ige M;Wang T;Isaji T;Kudze T;Liu H;Yatsula B;Hashimoto T;Xing Y;Dardik A
聚酯通常用于血管外科手术中的补片血管成形术和移植物。我们假设，聚酯补片愈合的动脉或静脉祖细胞的浸润取决于植入部位。将聚酯补片植入Wistar大鼠主动脉或下腔静脉，并在第7天或第30天缝合。与动脉环境中的补片上形成的量相比，静脉环境中聚酯补片上形成的新生内膜更厚。静脉斑块有更多的细胞增殖和更多的VCAM阳性和CD 68阳性细胞，而动脉斑块有更多的波形蛋白阳性和α-肌动蛋白阳性细胞。虽然在新生内膜内皮中有相似数量的内皮祖细胞，但动脉斑块中的细胞为Ephrin-B2和notch-4阳性，而静脉斑块中的细胞为Eph-B4和COUP-TFII阳性。用动静脉瘘治疗的静脉补片新生内膜厚度降低;新生内膜内皮细胞表达Ephrin-B2和notch-4以及Eph-B4和COUP-TFII。静脉环境中的聚酯补片获得静脉身份，而动脉环境中的补片获得动脉身份;瘘管环境中的补片获得双重动静脉身份。这些数据表明，合成补丁愈合收购的身份，他们的环境。
Polyester is commonly used in vascular surgery for patch angioplasty and grafts. We hypothesized that polyester patches heal by infiltration of arterial or venous progenitor cells depending on the site of implantation. Polyester patches were implanted into the Wistar rat aorta or inferior vena cava and explanted on day 7 or 30. Neointima that formed on polyester patches was thicker in the venous environment compared to the amount that formed on patches in the arterial environment. Venous patches had more cell proliferation and greater numbers of VCAM-positive and CD68-positive cells, whereas arterial patches had greater numbers of vimentin-positive and alpha-actin-positive cells. Although there were similar numbers of endothelial progenitor cells in the neointimal endothelium, cells in the arterial patch were Ephrin-B2- and notch-4-positive while those in the venous patch were Eph-B4- and COUP-TFII-positive. Venous patches treated with an arteriovenous fistula had decreased neointimal thickness; neointimal endothelial cells expressed Ephrin-B2 and notch-4 in addition to Eph-B4 and COUP-TFII. Polyester patches in the venous environment acquire venous identity, whereas patches in the arterial environment acquire arterial identity; patches in the fistula environment acquire dual arterial-venous identity. These data suggest that synthetic patches heal by acquisition of identity of their environment.
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影响因子：
0.9
作者：
Hingorani, Anil P;Ascher, Enrico;Jacob, Theresa
通讯作者：
Jacob, Theresa
DOI：
10.1016/j.ejvs.2003.12.003
发表时间：
2004-02-01
影响因子：
5.7
作者：
Laurila, K;Lepäntalo, M;Lehtola, A
通讯作者：
Lehtola, A
影响因子：
4.3
作者：
GREISLER, HP;DENNIS, JW;BURGESS, W
通讯作者：
BURGESS, W
影响因子：
2.5
作者：
Bai H;Wang M;Foster TR;Hu H;He H;Hashimoto T;Hanisch JJ;Santana JM;Xing Y;Dardik A
通讯作者：
Dardik A
影响因子：
9.3
作者：
Hristov, Mihail;Weber, Christian
通讯作者：
Weber, Christian