Effects of the Co-occurrence of Diabetes Mellitus and Tooth Loss on Cognitive Function.
Effects of the Co-occurrence of Diabetes Mellitus and Tooth Loss on Cognitive Function.
复制标题
DOI：
10.2174/1567205019666211223093057
复制
发表时间：
2021
影响因子：
2.1
通讯作者：
Wu B
中科院分区：
文献类型：
--
作者：
Luo H;Tan C;Adhikari S;Plassman BL;Kamer AR;Sloan FA;Schwartz MD;Qi X;Wu B
糖尿病（DM）和口腔健康不良是老年人中常见的慢性疾病和阿尔茨海默病及相关痴呆症的危险因素。本研究评估了糖尿病和牙齿完全缺失（TL）对认知功能的影响，并解释了它们之间的相互作用。纵向数据来自2006年，2012年和2018年的健康和退休研究浪潮。这项队列研究包括7，805名年龄在65岁或以上的受访者，观察人数为18，331人年。DM和完全TL均为自我报告。认知功能通过认知状态电话访谈进行测量。使用随机效应回归来检验总体和按性别分层的相关性。与既无DM也无完全TL的老年人相比，（B = −1.35，95%置信区间[CI]：−1.68，−1.02）、单独完全TL（B = −0.67，95% CI：−0.88，−0.45）或单独DM（B = −0.40，95% CI：−0.59，−0.22）的认知评分较低。两种情况的影响明显大于单独DM（p <0.001）或单独完全TL（p = 0.001）。性别分层分析显示，男性和女性的影响是相似的，除了单独患有糖尿病的男性不显着。DM和完全性TL的共同发生对认知造成了额外的风险。医疗保健和家庭护理提供者应注意糖尿病和完全TL患者的认知健康。需要继续努力改善老年人获得牙科护理的机会，特别是对糖尿病患者。
Both diabetes mellitus (DM) and poor oral health are common chronic conditions and risk factors of Alzheimer’s disease and related dementia among older adults. This study assessed the effects of DM and complete tooth loss (TL) on cognitive function, accounting for their interactions. Longitudinal data were obtained from the 2006, 2012, and 2018 waves of the Health and Retirement Study. This cohort study included 7,805 respondents aged 65 years or older with 18,331 person-year observations. DM and complete TL were self-reported. Cognitive function was measured by the Telephone Interview for Cognitive Status. Random-effect regressions were used to test the associations, overall and stratified by sex. Compared with older adults without neither DM nor complete TL, those with both conditions (b = −1.35, 95% confidence interval [CI]: −1.68, −1.02), with complete TL alone (b = −0.67, 95% CI: −0.88, −0.45), or with DM alone (b = −0.40, 95% CI: −0.59, −0.22), had lower cognitive scores. The impact of having both conditions was significantly greater than that of having DM alone (p < .001) or complete TL alone (p = 0.001). Sex-stratified analyses showed the effects were similar in males and females, except having DM alone was not significant in males. The co-occurrence of DM and complete TL poses an additive risk for cognition. Healthcare and family-care providers should pay attention to the cognitive health of patients with both DM and complete TL. Continued efforts are needed to improve older adults’ access to dental care, especially for individuals with DM.
登录
查看更多内容
影响因子：
5.5
作者：
Luo H;Pan W;Sloan F;Feinglos M;Wu B
通讯作者：
Wu B
影响因子：
7.6
作者：
Hasegawa, Y.;Ono, T.;Nokubi, T.
通讯作者：
Nokubi, T.
DOI：
10.1111/j.1532-5415.2012.04154.x
发表时间：
2012-10-01
影响因子：
6.3
作者：
Lexomboon, Duangjai;Trulsson, Mats;Parker, Marti G.
通讯作者：
Parker, Marti G.
DOI：
10.1111/j.1532-5415.2005.00522.x
发表时间：
2006-01-01
影响因子：
6.3
作者：
Kuo, HK;Jones, RN;Lipsitz, LA
通讯作者：
Lipsitz, LA
影响因子：
3.3
作者：
Mayeda ER;Whitmer RA;Yaffe K
通讯作者：
Yaffe K