Diabetes and cognition.
Diabetes and cognition.
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DOI：
10.1016/j.cger.2014.08.021
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发表时间：
2015-02
影响因子：
3.3
通讯作者：
Yaffe K
中科院分区：
文献类型：
--
作者：
Mayeda ER;Whitmer RA;Yaffe K
痴呆症是老年人致残的主要原因，也是美国老年人死亡的第五大原因。来自流行病学研究的证据表明，患有2型糖尿病（T2D）的老年人患痴呆症的可能性比没有T2D的老年人高50-100%。然而，关于T2D对认知能力下降影响的研究还不太明确，这种关联是否反映了T2D与痴呆发病机制之间的因果关系仍有待确定。T2D可能导致认知能力下降和痴呆的机制有多种，包括胰岛素失调和慢性高血糖对阿尔茨海默病和大脑血管病理的影响。神经病理学和神经影像学研究表明，脑梗死和脑萎缩在老年T2D患者中更为常见。卫生保健提供者应意识到老年T2D患者患痴呆的风险增加，并应注意老年T2D患者的认知问题。需要更多的研究来阐明T2D和痴呆之间的联系，并确定维持T2D患者认知功能的策略。
Dementia is a major cause of disability among older adults and is the fifth leading cause of death among older adults in the U.S. Evidence from epidemiologic studies suggest older adults with type 2 diabetes (T2D) are 50-100% more likely to develop dementia than those without T2D. However, studies examining the effect of T2D on cognitive decline have been less definitive, and it remains to be determined whether this association reflects a causal relationship between T2D and dementia pathogenesis. There are multiple proposed mechanisms through which T2D could cause cognitive decline and dementia, including the effects of insulin dysregulation and chronic hyperglycemia on both Alzheimer's disease and vascular pathology in the brain. Neuropathological and neuroimaging studies suggest that cerebral infarcts and brain atrophy are more common in older adults with T2D. Health care providers should be aware that older adults with T2D have an increased risk for development of dementia and should be attentive in looking for cognitive problems in older patients with T2D. More research is needed to elucidate the link between T2D and dementia and to identify strategies to maintain cognitive function among people with T2D.
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DOI：
10.1093/gerona/60.4.471
发表时间：
2005-04-01
影响因子：
5.1
作者：
Beeri, MS;Silverman, JM;Haroutunian, V
通讯作者：
Haroutunian, V
与中年和老年人的心血管危险因素有关的痴呆症住院风险：社区中的动脉粥样硬化风险（ARIC）研究。
影响因子：
11
作者：
Alonso, A.;Mosley, T. H., Jr.;Gottesman, R. F.;Catellier, D.;Sharrett, A. R.;Coresh, J.
通讯作者：
Coresh, J.
DOI：
10.1152/ajpendo.91041.2008
发表时间：
2009-07-01
影响因子：
5.1
作者：
Bree, Adam J.;Puente, Erwin C.;Fisher, Simon J.
通讯作者：
Fisher, Simon J.
影响因子：
16.2
作者：
Espeland MA;Bryan RN;Goveas JS;Robinson JG;Siddiqui MS;Liu S;Hogan PE;Casanova R;Coker LH;Yaffe K;Masaki K;Rossom R;Resnick SM;WHIMS-MRI Study Group
通讯作者：
WHIMS-MRI Study Group
影响因子：
2.4
作者：
Cheng, D.;Noble, J.;Luchsinger, J. A.
通讯作者：
Luchsinger, J. A.