Intensive therapy induces contralateral white matter changes in chronic stroke patients with Broca's aphasia.
Intensive therapy induces contralateral white matter changes in chronic stroke patients with Broca's aphasia.
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DOI：
10.1016/j.bandl.2014.03.011
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发表时间：
2014-09
影响因子：
2.5
通讯作者：
Schlaug, Gottfried
中科院分区：
文献类型：
--
作者：
Wan, Catherine Y.;Zheng, Xin;Marchina, Sarah;Norton, Andrea;Schlaug, Gottfried
关键词：
采用前后设计，11例左半球大面积病变和非流利性失语的慢性卒中患者在接受15周强化语调言语治疗前后接受了弥散张量成像和语言测试。将该治疗患者组与在相似时间段内扫描两次的未治疗患者组（n=9）进行比较。我们的研究结果表明，治疗组，而不是未治疗组，有减少的部分各向异性的白色物质下方的右额下回（IFG，部盖和部三角），右后上级颞回，并在右后扣带回。此外，我们发现，语音产生的更大改善与右侧IFG（眼睑部）FA的更大减少相关。因此，我们的研究结果表明，非流利性失语症患者的强化康复计划导致了右半球的结构变化，这与言语产生的改善有关。
Using a pre-post design, eleven chronic stroke patients with large left hemisphere lesions and nonfluent aphasia underwent diffusion tensor imaging and language testing before and after receiving 15 weeks of an intensive intonation-based speech therapy. This treated patient group was compared to an untreated patient group (n=9) scanned twice over a similar time period. Our results showed that the treated group, but not the untreated group, had reductions in fractional anisotropy in the white matter underlying the right inferior frontal gyrus (IFG, pars opercularis and pars triangularis), the right posterior superior temporal gyrus, and in the right posterior cingulum. Furthermore, we found that greater improvements in speech production were associated with greater reductions in FA in the right IFG (pars opercularis). Thus, our findings showed that an intensive rehabilitation program for patients with non-fluent aphasia led to structural changes in the right hemisphere, which correlated with improvements in speech production.
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影响因子：
9.9
作者：
Raboyeau, G.;De Boissezon, X.;Cardebat, D.
通讯作者：
Cardebat, D.
影响因子：
14.5
作者：
Richter, Maria;Miltner, Wolfgang H. R.;Straube, Thomas
通讯作者：
Straube, Thomas
DOI：
10.1523/jneurosci.2227-10.2010
发表时间：
2010-09-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fridriksson J
通讯作者：
Fridriksson J
DOI：
10.1044/jshr.3602.338
发表时间：
1993-04-01
期刊：
JOURNAL OF SPEECH AND HEARING RESEARCH
影响因子：
--
作者：
NICHOLAS, LE;BROOKSHIRE, RH
通讯作者：
BROOKSHIRE, RH
影响因子：
3.4
作者：
Meister, Ingo G.;Buelte, Dorothee;Sparing, Roland
通讯作者：
Sparing, Roland