Methylene blue modulates functional connectivity in the human brain.
Methylene blue modulates functional connectivity in the human brain.
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DOI：
10.1007/s11682-016-9541-6
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发表时间：
2017-06
影响因子：
3.2
通讯作者：
Duong, Timothy Q.
中科院分区：
文献类型：
--
作者：
Rodriguez, Pavel;Singh, Amar P.;Malloy, Kristen E.;Zhou, Wei;Barrett, Douglas W.;Franklin, Crystal G.;Altmeyer, Wilson B.;Gutierrez, Juan E.;Li, Jinqi;Heyl, Betty L.;Lancaster, Jack L.;Gonzalez-Lima, F.;Duong, Timothy Q.
亚甲基蓝USP （MB）是一种获得fda批准的药物，用于治疗高铁血红蛋白血症、一氧化碳中毒和氰化物中毒，该药物已被证明可以增加啮齿动物fMRI诱发的血氧水平依赖（BOLD）反应。低剂量MB对啮齿动物和人类也有增强记忆的作用。然而，MB在人脑中的作用的神经相关性尚不清楚。我们测试了单次低剂量口服MB调节健康成人神经网络功能连通性的假设。采用随机、双盲、安慰剂对照设计，在MB或安慰剂给药前和给药后一小时分别进行任务型和无任务型功能磁共振成像。在视觉运动任务期间，给药MB与任务相关网络的脑血流量减少有关，并且与连接感知和记忆功能的多个区域的静息状态功能连通性更强有关。这些发现首次证明了低剂量MB可以调节人脑中任务相关和静息状态的神经网络。这些神经影像学发现支持在健康人群和疾病人群中进一步调查。
Methylene blue USP (MB) is a FDA-grandfathered drug used in clinics to treat methemoglobinemia, carbon monoxide poisoning and cyanide poisoning that has been shown to increase fMRI evoked blood oxygenation level dependent (BOLD) response in rodents. Low dose MB also has memory enhancing effect in rodents and humans. However, the neural correlates of the effects of MB in the human brain are unknown. We tested the hypothesis that a single low oral dose of MB modulates the functional connectivity of neural networks in healthy adults. Task-based and task-free fMRI were performed before and one hour after MB or placebo administration utilizing a randomized, double-blinded, placebo-controlled design. MB administration was associated with a reduction in cerebral blood flow in a task-related network during a visuomotor task, and with stronger resting-state functional connectivity in multiple regions linking perception and memory functions. These findings demonstrate for the first time that low-dose MB can modulate task-related and resting-state neural networks in the human brain. These neuroimaging findings support further investigations in healthy and disease populations.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
亚甲蓝治疗可延缓永久性缺血性中风中灌注扩散失配至梗塞的进展。
影响因子：
2.9
作者：
Rodriguez P;Jiang Z;Huang S;Shen Q;Duong TQ
通讯作者：
Duong TQ
影响因子：
2.9
作者：
Pamplona GS;Santos Neto GS;Rosset SR;Rogers BP;Salmon CE
通讯作者：
Salmon CE
影响因子：
5.7
作者：
Maldjian, JA;Laurienti, PJ;Burdette, JH
通讯作者：
Burdette, JH
影响因子：
2.9
作者：
Peter, C;Hongwan, D;Lauterburg, BH
通讯作者：
Lauterburg, BH