The others: our biased perspective of eukaryotic genomes.

The others: our biased perspective of eukaryotic genomes.
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DOI:
10.1016/j.tree.2014.03.006
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发表时间:
2014-05
影响因子:
16.8
通讯作者:
Ruiz-Trillo I
Ruiz-Trillo I
中科院分区:
生物学1区
文献类型:
--
作者:
del Campo J;Sieracki ME;Molestina R;Keeling P;Massana R;Ruiz-Trillo I

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了解真核细胞的起源和进化以及真核生物的多样性与许多生物学科有关。然而,我们目前对真核生物基因组的理解是非常有偏见的,导致了对真核生物学的偏见。我们认为,一个生物学驱动的倡议,以涵盖整个真核生物的多样性,需要克服这种偏见。我们鼓励社区:(i)对公共培养物收藏中可获得的被忽视群体的代表进行测序,(ii)增加我们的培养努力,以及(iii)采用单细胞基因组学来获得难以在培养物中繁殖的生物体。我们希望社区将欢迎这一建议,探索所建议的方法,并共同努力对真核生物的全部多样性进行测序。
Understanding the origin and evolution of the eukaryotic cell and the full diversity of eukaryotes is relevant to many biological disciplines. However, our current understanding of eukaryotic genomes is extremely biased, leading to a skewed view of eukaryotic biology. We argue that a phylogeny-driven initiative to cover the full eukaryotic diversity is needed to overcome this bias. We encourage the community: (i) to sequence a representative of the neglected groups available at public culture collections, (ii) to increase our culturing efforts, and (iii) to embrace single cell genomics to access organisms refractory to propagation in culture. We hope that the community will welcome this proposal, explore the approaches suggested, and join efforts to sequence the full diversity of eukaryotes.
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