Psoriasis and the risk of diabetes: A prospective population-based cohort study.
Psoriasis and the risk of diabetes: A prospective population-based cohort study.
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DOI：
10.1016/j.jaad.2017.10.050
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发表时间：
2018-03
影响因子：
13.8
通讯作者：
Gelfand JM
中科院分区：
文献类型：
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作者：
Wan MT;Shin DB;Hubbard RA;Noe MH;Mehta NN;Gelfand JM
缺乏客观测量银屑病严重程度对2型糖尿病（T2 DM）风险影响的评估数据。确定银屑病患者与无银屑病成人相比的T2 DM风险，按银屑病影响的直接评估体表面积（BSA）类别分层。一项来自英国的前瞻性、基于人群的队列研究。对8，124名银屑病成人和76，599名无银屑病成人进行了约4年的前瞻性随访。银屑病组中有280例（3.44%）糖尿病病例，无银屑病组中有1867例（2.44%）糖尿病病例。校正年龄、性别和体重指数后，与无银屑病患者相比，≤2BSA、3-10%BSA和>10%BSA组发生糖尿病的风险比（95%CI）分别为1.21（1.01-1.44）、1.01（0.81-1.26）和1.64（1.23-2.18）（趋势p=0.004）。在全球范围内，我们估计与未患银屑病的患者相比，每年新增125，650例T2 DM诊断。相对短期的随访和排除患病率病例，这些病例可能与不太广泛的银屑病患者有隐藏的关联。临床医生可以测量受银屑病影响的BSA，以针对银屑病患者的糖尿病预防工作。
Data evaluating the impact of objectively measured psoriasis severity on type 2 diabetes mellitus (T2DM) risk are lacking. To determine the risk of T2DM in patients with psoriasis compared to adults without psoriasis, stratified by categories of directly assessed body surface area (BSA) affected by psoriasis. A prospective, population-based, cohort study from the UK. 8,124 adults with psoriasis and 76,599 adults without psoriasis were followed prospectively for approximately 4 years. 280 (3.44%) incident cases of diabetes in the psoriasis group and 1867 (2.44%) incident cases of diabetes in those without psoriasis. After adjusting for age, sex and body mass index, the hazard ratios (95%CI) for developing incident diabetes were 1.21 (1.01–1.44), 1.01 (0.81–1.26), and 1.64 (1.23–2.18) in the ≤2BSA, 3–10%BSA, and >10%BSA groups compared to those without psoriasis, respectively (p=0.004 for trend). Worldwide, we estimate an additional 125,650 new diagnoses of T2DM per year in patients with psoriasis as compared to those without. Relatively short-term follow-up and exclusion of prevalence cases which may have masked associations in patients with less extensive psoriasis. Clinicians may measure BSA affected by psoriasis in order to target diabetes prevention efforts for patients with psoriasis.
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影响因子：
120.7
作者：
Gelfand, Joel M.;Neimann, Andrea L.;Troxel, Andrea B.
通讯作者：
Troxel, Andrea B.
牛皮癣与糖尿病和高血压的风险：一项针对美国女护士的前瞻性研究。
影响因子：
--
作者：
Qureshi, Abrar A.;Choi, Hyon K.;Setty, Arathi R.;Curhan, Gary C.
通讯作者：
Curhan, Gary C.
影响因子：
13.8
作者：
Gelfand, JM;Feldman, SR;Margolis, DJ
通讯作者：
Margolis, DJ
影响因子：
10.9
作者：
Takeshita J;Wang S;Shin DB;Mehta NN;Kimmel SE;Margolis DJ;Troxel AB;Gelfand JM
通讯作者：
Gelfand JM
影响因子：
3.7
作者：
Armstrong, April W.;Lin, Steven W.;Chin, David L.
通讯作者：
Chin, David L.