Immunohistochemical analysis of aromatase in metastatic lymph nodes of breast cancer
Immunohistochemical analysis of aromatase in metastatic lymph nodes of breast cancer
复制标题
乳腺癌转移淋巴结芳香酶的免疫组织化学分析
作者：
Shibahara Y;Miki Y;Ishida T;Nakamura Y;Suzuki T;Ohuchi N;Sasano H
芳香化酶是绝经后乳腺癌瘤内雌激素生成的关键酶，第三代芳香化酶抑制剂可有效抑制该酶反应。芳香化酶抑制剂通常用于转移性乳腺癌患者，其中雌激素受体仅在原发肿瘤中被证明，而不是转移部位。迄今为止，转移部位芳香化酶的状态尚未得到很好的表征。我们用免疫组化法对46例雌激素受体阳性的原发性乳腺癌和配对的转移淋巴结中的芳香化酶进行了免疫定位。在46例原发性肿瘤和46例转移性淋巴结中检测到免疫反应性。芳香化酶在原发灶和转移灶的状态之间存在显著相关性。芳香化酶免疫反应性与年龄、原发肿瘤大小和Ki-67指数相关。在淋巴结周围的脂肪组织中也检测到芳香化酶免疫反应。总之，芳香化酶在原发肿瘤中的状态通常代表其在转移淋巴结中的状态。这表明雌激素受体阳性肿瘤的内分泌环境在转移过程中保持稳定。
Aromatase is the key enzyme in intratumoral estrogen production in postmenopausal breast cancer and third generation aromatase inhibitors suppress this enzymatic reaction effectively. Aromatase inhibitor is administered to metastatic breast cancer patients customarily in which estrogen receptor had been demonstrated only in the primary tumor, not the metastatic sites. The status of aromatase in metastatic sites has not been well‐characterized to date. We immunolocalized aromatase in 46 estrogen receptor positive primary breast cancers and paired metastatic lymph nodes, using immunohistochemistry. Immunoreactivity was detected in 44/46 primary tumors and 40/46 metastatic lymph nodes. A significant correlation was detected between the status of aromatase in primary and metastatic sites. Aromatase immunoreactivity was correlated with age, size of primary tumor and Ki‐67 index. Aromatase immunoreactivity was also detected in adipose tissue surrounding the lymph nodes. In conclusion, aromatase status in primary tumors generally represents its status in metastatic lymph nodes. This indicates that the endocrine environment of estrogen receptor positive tumors remain stable during the metastatic process.
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影响因子：
3.8
作者：
D'Andrea, Mario R.;Limiti, Maria R.;Mingazzini, Pietro L.
通讯作者：
Mingazzini, Pietro L.
影响因子：
11.2
作者：
Miki, Yasuhiro;Suzuki, Takashi;Sasano, Hironobu
通讯作者：
Sasano, Hironobu
DOI：
10.1056/nejmoa0810818
发表时间：
2009-08-20
期刊：
The New England journal of medicine
影响因子：
--
作者：
BIG 1-98 Collaborative Group;Mouridsen H;Giobbie-Hurder A;Goldhirsch A;Thürlimann B;Paridaens R;Smith I;Mauriac L;Forbes J;Price KN;Regan MM;Gelber RD;Coates AS
通讯作者：
Coates AS
DOI：
10.1111/j.1742-1241.2005.00546.x
发表时间：
2005-09-01
影响因子：
2.6
作者：
Dikicioglu, E;Barutca, S;Meteoglu, I
通讯作者：
Meteoglu, I
影响因子：
168.9
作者：
Coombes, R. C.;Kilburn, L. S.;Bliss, J. M.
通讯作者：
Bliss, J. M.