The hormetic functions of Wnt pathways in tubular injury.
The hormetic functions of Wnt pathways in tubular injury.
复制标题
DOI：
10.1007/s00424-017-2018-7
复制
发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Gröne HJ
中科院分区：
文献类型：
--
作者：
Gröne EF;Federico G;Nelson PJ;Arnold B;Gröne HJ
慢性肾小管间质损伤伴肾小管上皮萎缩和间质纤维化是慢性肾病（CKD）的标志，也是CKD进展的预测因子。几个实验现在已经提供了Wnt信号通路显著促进萎缩和纤维化的证据;相反，也已经表明Wnt系统促进急性肾小管损伤中的再生过程。我们现在已经证明Dickkopf 3（DKK 3）是CKD中经典Wnt信号传导的激动剂，并促进肾小管间质室的慢性纤维化炎症。DKK 3的遗传和抗体介导的抑制导致肾小管分化的显著改善和纤维化的减少。此外，分泌的糖蛋白DKK 3可用作人类CKD程度的非侵入性尿液标志物。
Chronic tubulointerstitial damage with tubular epithelial atrophy and interstitial fibrosis is the hallmark of chronic kidney disease (CKD) and a predictor for progression of CKD. Several experiments have now provided evidence that the Wnt signaling pathways are significantly contributing to atrophy and fibrosis; in contrast, it also has been shown that the Wnt system fosters regenerative processes in acute tubular injury. We now have demonstrated that Dickkopf 3 (DKK3) is an agonist for canonical Wnt signaling in CKD and fosters chronic fibrosing inflammation of the tubulointerstitial compartment. Genetic- and antibody-mediated inhibition of DKK3 leads to a pronounced improvement of tubular differentiation and a reduction in fibrosis. In addition, the secreted glycoprotein DKK3 can be used as a non-invasive urinary marker for the extent of CKD in man.
登录
查看更多内容
DOI：
10.1038/nrneph.2016.54
发表时间：
2016-07
期刊：
Nature reviews. Nephrology
影响因子：
--
作者：
Edeling M;Ragi G;Huang S;Pavenstädt H;Susztak K
通讯作者：
Susztak K
影响因子：
64.8
作者：
Glinka, A;Wu, W;Niehrs, C
通讯作者：
Niehrs, C
影响因子：
19.6
作者：
Madan B;Patel MB;Zhang J;Bunte RM;Rudemiller NP;Griffiths R;Virshup DM;Crowley SD
通讯作者：
Crowley SD
影响因子：
4
作者：
Kohn, AD;Moon, RT
通讯作者：
Moon, RT
影响因子：
4.4
作者：
Ludwig, Julia;Federico, Giuseppina;Arnold, Bernd
通讯作者：
Arnold, Bernd