Vaccination against Q fever for biodefense and public health indications.
Vaccination against Q fever for biodefense and public health indications.
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DOI：
10.3389/fmicb.2014.00726
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发表时间：
2014
影响因子：
5.2
通讯作者：
Wolfe DN
中科院分区：
文献类型：
--
作者：
Ruiz S;Wolfe DN
伯纳蒂克希菌是Q热的病原体，Q热是一种通常通过吸入受污染农业来源的细菌而传播给人类的疾病。世界各地都观察到疫情爆发，更大的焦点引起了人们对疫苗接种计划的兴趣，尤其是在澳大利亚和荷兰。重要的是，部署到中东的军事人员的暴露率可能相对较高，通过血清转化为伯纳氏杆菌特异性抗体来测量。由于其低感染剂量和环境稳定性，Q热多年来一直引起生物防御界的兴趣。伯纳氏梭菌的无细胞生长和遗传学的最新进展也使这种生物更容易培养和操作。虽然有一种疫苗获准在澳大利亚使用，但与Q热相关的生物防御和公共健康问题的结合，要求开发一种更安全、更有效的疫苗来预防这种疾病。
Coxiella burnetii is the etiological agent of Q fever, a disease that is often spread to humans via inhalational exposure to the bacteria from contaminated agricultural sources. Outbreaks have been observed all over the world with larger foci generating interest in vaccination programs, most notably in Australia and the Netherlands. Importantly, exposure rates among military personnel deployed to the Middle East can be relatively high as measured by seroconversion to C. burnetii-specific antibodies. Q fever has been of interest to the biodefense community over the years due to its low infectious dose and environmental stability. Recent advances in cell-free growth and genetics of C. burnetii also make this organism easier to culture and manipulate. While there is a vaccine that is licensed for use in Australia, the combination of biodefense- and public health-related issues associated with Q fever warrant the development of a safer and more effective vaccine against this disease.
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