Q fever: a neglected zoonosis in Saudi Arabia.
Q fever: a neglected zoonosis in Saudi Arabia.
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DOI：
10.5144/0256-4947.2013.464
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发表时间：
2013-09
影响因子：
1.6
通讯作者：
Adam MH
中科院分区：
文献类型：
--
作者：
Almogren A;Shakoor Z;Hasanato R;Adam MH
临床实践中很少寻找 Q 热的病原体伯内特柯克斯体 (C burnetii) 引起的感染。本研究旨在检测不明原因发热 (PUC) 患者的伯内特念珠菌感染。这是一项于 2011 年 3 月至 2013 年 1 月在利雅得国王哈立德大学医院进行的前瞻性研究。从利雅得哈立德国王大学医院的 51 名 PUC 患者中采集了总共 3 mL 的静脉血。本组患者包括 30 名男性和 21 名女性（平均年龄 33.9 [21.3] 岁），有 4 至 8 周的发热病史。该研究还包括由 50 名健康个体组成的对照组，其中包括 39 名男性和 11 名女性（平均年龄 27 [9] 岁）。通过免疫荧光法检测 II C 期伯内氏特异性 IgG 抗体，效价 >1:64 被认为是阳性。在 51 名接受测试的患者中，有 18 名 (35.2%) 患者检测到 II 期 C 伯内特特异性 IgG 抗体。对照组 50 人中有两人 (4%) 检测出抗伯氏梭菌 IgG 抗体呈阳性。患者中阳性结果的比例显着高于对照组（P<.0002，95% CI，15.09-46.25）。抗体滴度范围在1:128至1:1024之间，其中6名患者的滴度为1:256，5名患者的滴度为1:512，4名患者的滴度为1:124，3名患者的滴度为1:128。大量患者存在伯内特念珠菌感染的证据强调需要对 PUC 患者进行 Q 热血清学检查。
Infection due to Coxiella burnetii (C burnetii), the causative agent of Q fever is rarely sought for in clinical practice. This study was performed to detect C burnetii infection in patients with pyrexia of undetermined cause (PUC). This is a prospective study conducted at King Khalid University Hospital, Riyadh between March 2011 and January 2013. A total of 3 mL venous blood was collected from 51 patients with PUC at King Khalid University Hospital, Riyadh. This group of patients included 30 males and 21 females (mean age 33.9 [21.3] years) with the history of febrile illness ranging between 4 and 8 weeks. A control group of 50 healthy individuals comprising 39 males and 11 females (mean age 27 [9] years) was also included in the study. Detection of phase II C burnetii–specific IgG antibodies was performed by immunofluorescence assay, and a titer of >1:64 was considered positive. Phase II C burnetii–specific IgG antibodies were detected in 18 (35.2%) patients out of the total 51 tested. Two (4%) individuals out of 50 in the control group tested positive for anti–C burnetii IgG antibodies. The proportion of positive results among the patients was significantly higher than the controls (P<.0002, 95% CI, 15.09–46.25). The antibody titer range was between 1:128 and 1:1024 where 6 patients had titers of 1:256, 5 had 1:512, 4 had 1024, and 3 had 1:128. The evidence of C burnetii infection in a sizable number of patients emphasizes the need for inclusion of serologic investigations for Q fever in patients with PUC.
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影响因子：
11.8
作者：
Carrascosa, M;Pascual, F;Napal, J
通讯作者：
Napal, J
影响因子：
11.4
作者：
MURPHY, AM;FIELD, PR
通讯作者：
FIELD, PR
影响因子：
12
作者：
Terheggen, Ulrich;Leggat, Peter A
通讯作者：
Leggat, Peter A
影响因子：
11.8
作者：
Fenollar, F;Fournier, PE;Raoult, D
通讯作者：
Raoult, D
DOI：
10.4269/ajtmh.2009.09-0168
发表时间：
2009-10-01
影响因子：
3.3
作者：
Anderson, Alicia D.;Kruszon-Moran, Deanna;Massung, Robert F.
通讯作者：
Massung, Robert F.