Lower incidence of seizure among neonates treated with therapeutic hypothermia.
Lower incidence of seizure among neonates treated with therapeutic hypothermia.
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DOI：
10.1177/0883073813507978
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发表时间：
2014-11
影响因子：
1.9
通讯作者：
Glass HC
中科院分区：
文献类型：
--
作者：
Orbach SA;Bonifacio SL;Kuzniewicz MW;Glass HC
Animal studies suggest that hypothermia decreases seizure burden, while limited human data are inconclusive. This retrospective cohort study examines the relationship between therapeutic hypothermia and seizure in neonates with hypoxic-ischemic encephalopathy. Our center admitted 224 neonates from July 2004 to December 2011 who met institutional cooling criteria. Seventy-three neonates were born during the pre-cooling era, prior to November 2007, and 151 were born during the cooling era. Among neonates with moderate encephalopathy, the incidence of seizure in cooled infants was less than half the incidence in those not cooled (26% cooling versus 61% pre-cooling era; RR=0.43, 95% CI 0.30 to 0.61). Among neonates with severe encephalopathy, there was no difference in the incidence (83% versus 87%; RR=1.05, 95% CI 0.78 to 1.39). These results support animal data and suggest a mechanism by which neonates with moderate encephalopathy may benefit more from cooling than neonates with severe encephalopathy.
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影响因子：
1.9
作者：
Harbert MJ;Tam EW;Glass HC;Bonifacio SL;Haeusslein LA;Barkovich AJ;Jeremy RJ;Rogers EE;Glidden DV;Ferriero DM
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