White matter integrity and five-factor personality measures in healthy adults.
White matter integrity and five-factor personality measures in healthy adults.
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DOI：
10.1016/j.neuroimage.2011.07.040
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发表时间：
2012-01-02
期刊：
影响因子：
5.7
通讯作者：
Potenza, Marc N.
中科院分区：
文献类型：
--
作者：
Xu, Jiansong;Potenza, Marc N.
五因素模型将人格特质分为五个因素：神经质、外向性、开放性、宜人性和尽责性。对这些人格特征的测量可以预测人们的行为及其生活的重要结果。因此，了解这些人格特征的神经关联非常重要。本研究使用弥散张量成像 (DTI) 和修订版 NEO 人格量表 (NEO-PI-R) 评估了 51 名健康参与者的白质 (WM) 完整性和人格特质之间的关系。神经质呈正相关，而开放性和宜人性与辐射冠和上纵束（连接前额皮质（PFC）、顶叶皮质和皮质下结构的束）的 DTI 平均扩散率（MD）呈负相关。此外，神经质与前扣带回和钩束、连接前额皮层和杏仁核的束的MD呈正相关。开放度与两个半球背外侧 PFC 附近 WM 的 MD 呈负相关。这些发现表明，更大的神经质与互连广泛的皮层和皮层下结构（包括前额皮质和杏仁核）的 WM 完整性较差相关，而更大的开放性与互连广泛的皮层和皮层下结构（包括背外侧 PFC）的 WM 更好的完整性相关。
The five-factor model organizes personality traits into five factors: Neuroticism, Extraversion, Openness to Experience, Agreeableness, and Conscientiousness. Measures of these personality traits predict people’s behaviors and important outcomes of their lives. Therefore, understanding the neural correlates of these personality traits is important. This study assessed the relationships between white matter (WM) integrity and personality traits among 51 healthy participants using diffusion tensor imaging (DTI) and the revised NEO Personality Inventory (NEO-PI-R). Neuroticism correlated positively while Openness and Agreeableness correlated negatively with DTI mean diffusivity (MD) in the corona radiata and superior longitudinal fasciculus, tracts which interconnect prefrontal cortex (PFC), parietal cortex, and subcortical structures. Furthermore, Neuroticism correlated positively with MD in the anterior cingulum and uncinate fasciculus, tracts interconnecting PFC and amygdala. Openness correlated negatively with MD of WM adjacent to the dorsolateral PFC in both hemispheres. These findings suggest that greater Neuroticism associates with worse integrity of WM interconnecting extensive cortical and subcortical structures including the PFC and amygdala and that greater Openness associates with better integrity of WM interconnecting extensive cortical and subcortical structures including the dorsolateral PFC.
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