Are uterine natural killer and plasma cells in infertility patients associated with endometriosis, repeated implantation failure, or recurrent pregnancy loss?
Are uterine natural killer and plasma cells in infertility patients associated with endometriosis, repeated implantation failure, or recurrent pregnancy loss?
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DOI：
10.1007/s00404-020-05679-z
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发表时间：
2020-12
影响因子：
2.6
通讯作者：
Bielfeld AP
中科院分区：
文献类型：
--
作者：
Freitag N;Pour SJ;Fehm TN;Toth B;Markert UR;Weber M;Togawa R;Kruessel JS;Baston-Buest DM;Bielfeld AP
不孕症是一种使世界各地数百万妇女遭受的衰弱状况，但不孕症和子宫内膜异位症之间的因果关系仍不清楚。我们假设，定义慢性子宫内膜炎的子宫自然杀伤细胞（uNK）和浆细胞（PC）的免疫细胞群在有或无子宫内膜异位症的患者中可能不同，因此与子宫内膜异位症相关的不孕症有关。我们的回顾性研究包括173例在月经周期的分泌期进行子宫内膜搔抓的患者，随后进行uNK细胞和PC的免疫组化检查。67例患者被诊断为子宫内膜异位症，106例作为对照组。与对照组相比，子宫内膜异位症女性中uNK细胞数量升高的风险并未增加。我们的研究结果表明，患有子宫内膜异位症的患者发生慢性子宫内膜炎（CE）的可能性是没有的患者的1.3倍，并且用强力霉素治疗可能会增加妊娠率。子宫内膜异位症和uNK细胞数量增加似乎无关。与最近发表的子宫内膜异位症、不孕症和uNK细胞增加之间的联系相反，我们没有发现任何证据表明子宫内膜异位症患者更容易出现子宫uNK细胞升高。计数子宫内膜活检中的PC可能是寻找非手术诊断子宫内膜异位症的生物标志物的一种新方法，因为我们的研究结果表明两者之间存在联系。
Infertility is a debilitating situation that millions of women around the world suffer from, but the causal relationship between infertility and endometriosis is still unclear. We hypothesize that the immune cell populations of uterine natural killer cells (uNK) and plasma cells (PC) which define chronic endometritis could differ in patients with or without endometriosis and therefore be the link to endometriosis-associated infertility. Our retrospective study includes 173 patients that underwent an endometrial scratching in the secretory phase of the menstrual cycle and subsequently immunohistochemical examination for uNK cells and PC. Sixty-seven patients were diagnosed with endometriosis, 106 served as the control cohort. The risk for an elevated number of uNK cells in women with endometriosis is not increased as compared to the control group. Our findings suggest that patients with endometriosis are 1.3 times more likely to have chronic endometritis (CE) as compared to those without and that the treatment with doxycycline might increase pregnancy rates. Endometriosis and an increased number of uNK cells seem to be unrelated. In contrast to the lately published connection between endometriosis, infertility and increased uNK cells, we could not find any evidence that patients with endometriosis are more prone to elevated uterine uNK cells. Counting of PC in endometrial biopsies might be a new approach in the search of biomarkers for the nonsurgical diagnosis of endometriosis since our findings suggest a connection.
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在子宫耐药性高的早期人类妊娠中，血管重塑的决定性自然杀伤细胞调节受损。
影响因子：
7.3
作者：
Fraser, Rupsha;Whitley, Guy Stj;Johnstone, Alan P.;Host, Amanda J.;Sebire, Neil J.;Thilaganathan, Baskaran;Cartwright, Judith E.
通讯作者：
Cartwright, Judith E.
影响因子：
6.7
作者：
Cicinelli, Ettore;Trojano, Giuseppe;de Ziegler, Dominique
通讯作者：
de Ziegler, Dominique
DOI：
10.1016/j.ijgo.2016.06.026
发表时间：
2016-12-01
影响因子：
3.8
作者：
Dakhly, Dina M. R.;Bayoumi, Yomna A.;El-Khayat, Waleed
通讯作者：
El-Khayat, Waleed
影响因子：
3.6
作者：
Kitaya, Kotaro;Matsubayashi, Hidehiko;Ishikawa, Tomomoto
通讯作者：
Ishikawa, Tomomoto
影响因子：
3.6
作者：
Kuon, Ruben-J.;Weber, Maja;Toth, Bettina
通讯作者：
Toth, Bettina