Exploring relationships between alcohol consumption, inflammation, and brain structure in a heavy drinking sample.
Exploring relationships between alcohol consumption, inflammation, and brain structure in a heavy drinking sample.
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DOI：
10.1111/acer.14712
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Hutchison KE
中科院分区：
文献类型：
--
作者：
Karoly HC;Skrzynski CJ;Moe EN;Bryan AD;Hutchison KE
长期饮酒与大脑结构的变化和整个大脑和身体的炎症信号增加有关。大脑中炎症的增加与结构性脑损伤有关。最近的研究也表明，神经细丝轻多肽(NFL)在神经元损伤后释放到循环中。因此，NFL已被提议作为神经退行性疾病的生物标记物，但尚未被探索与酒精使用障碍有关。对于这个二次数据分析，我们提出了一个概念性模型，将酗酒、促炎细胞因子IL-6、脑结构和NFL联系起来。在这项研究的182名参与者中，81名参与者拥有可用的灰质(GM)数据，80名参与者拥有可用的白质(WM)数据。其中一个子集有NFL(n=78)和IL-6(n=117)数据。用Freesurfer从额叶中段脑区提取GM厚度。平均WM扩散系数值从基于区域的空间统计中提取。测定血中NFL和IL-6水平。回归模型被用来检验概念模型中的个体联系。基于显著的回归结果，我们创建了一个简化的概念模型，并使用通径分析进行了检验。在回归中，GM与每天饮酒量(DPDD)(p=.018)和NFL(p=.004)之间出现了负相关。WM扩散率与DPDD呈正相关(p=0.033)。IL-6与饮酒、GM或WM没有显著关联。最终的路径模型显示，DPDD与额中回(MFG)厚度以及MFG厚度与NFL之间存在显著的负相关，但DPDD与NFL之间没有显著的关联。数据表明，饮酒与较低的GM厚度和较高的WM扩散率相关，而较低的GM厚度与较高的循环NFL相关。这是第一次在大量饮酒者的样本中证明大脑结构和NFL之间的联系的研究。
Chronic alcohol consumption is associated with structural brain changes and increased inflammatory signaling throughout the brain and body. Increased inflammation in the brain has been associated with structural brain damage. Recent studies have also shown that neurofilament light polypeptide (NfL) is released into circulation following neuronal damage. NfL has thus been proposed as a biomarker for neurodegenerative diseases but has not been explored in connection with alcohol use disorder. For this secondary data analysis, we proposed a conceptual model linking alcohol consumption, the pro-inflammatory cytokine IL-6, brain structure and NfL in heavy-drinking participants. Of the 182 individuals enrolled in this study, 81 participants had useable gray matter (GM) data and 80 had useable white matter (WM) data. A subset of these had NfL (n = 78) and IL-6 (n = 117) data. GM thickness was extracted from middle frontal brain regions using Freesurfer. Mean WM diffusivity values were extracted from Tract Based Spatial Statistics. NfL and IL-6 were measured from blood. Regression models were used to test individual linkages in the conceptual model. Based on significant regression results, we created a simplified conceptual model which was tested using path analysis. In regressions, negative relationships emerged between GM and both drinks per drinking day (DPDD) (p = .018) and NfL (p = .004). A positive relationship emerged between WM diffusivity and DPDD (p =.033). IL-6 was not significantly associated with alcohol use, GM or WM. The final path model demonstrated adequate fit to the data and showed significant, negative associations between DPDD and middle frontal gyrus (MFG) Thickness and between MFG Thickness and NfL, but a non-significant association between DPDD and NfL. Data suggest that drinking is associated with lower GM thickness and higher WM diffusivity and that lower GM thickness is associated with higher circulating NfL. This is the first study to demonstrate an association between brain structure and NfL in a sample of heavy drinkers.
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每天但不是间歇性酒精暴露后，神经免疫性基因表达的持续改变。
影响因子：
2.9
作者：
Gano A;Doremus-Fitzwater TL;Deak T
通讯作者：
Deak T
影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
DOI：
10.1111/j.1530-0277.2011.01452.x
发表时间：
2011-06
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Durazzo TC;Tosun D;Buckley S;Gazdzinski S;Mon A;Fryer SL;Meyerhoff DJ
通讯作者：
Meyerhoff DJ
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI
影响因子：
3.4
作者：
Donohue, B;Azrin, NH;Murphy, H
通讯作者：
Murphy, H