Maternal Inflammation During Pregnancy and Offspring Brain Development: The Role of Mitochondria.
Maternal Inflammation During Pregnancy and Offspring Brain Development: The Role of Mitochondria.
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DOI：
10.1016/j.bpsc.2021.11.003
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发表时间：
2022-05
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
作者：
在过去的几年中，人们越来越认识到怀孕期间母体免疫激活（MIA）与后代神经精神疾病风险之间的关联。在已描述的孕期母体炎症可能影响胎儿大脑发育的机制途径中，线粒体的作用很少受到关注。在当前的综述中，将提出线粒体作为妊娠期间 MIA 与后代大脑发育和精神疾病风险之间关联的潜在中介者的作用。作为这一假设的基础，提出了支持线粒体在大脑发育中的必然作用、线粒体作为炎症过程介质和引发剂的作用以及临床前 MIA 暴露模型和人类神经发育障碍中线粒体功能障碍的证据。阐明线粒体作为 MIA 诱导的大脑发育和神经发育疾病风险改变的潜在介质的作用，不仅可以为精神健康疾病的病理生理学提供新的见解，这些疾病的起源是在怀孕期间暴露于感染/免疫激活，而且还可以提供新的治疗靶点。
The association between maternal immune activation (MIA) during pregnancy and risk for offspring neuropsychiatric disorders has been increasingly recognized over the past several years. Among the mechanistic pathways that have been described through which maternal inflammation during pregnancy may affect fetal brain development, the role of mitochondria has received little attention. In the current review the role of mitochondria as a potential mediator of the association between MIA during pregnancy and offspring brain development and risk for psychiatric disorders will be proposed. As a basis for this postulation convergent evidence is presented supporting the obligatory role of mitochondria in brain development, the role of mitochondria as mediators and initiators of inflammatory processes, and evidence of mitochondrial dysfunction in pre-clinical MIA exposure models and human neurodevelopmental disorders. Elucidating the role of mitochondria as a potential mediator of MIA-induced alterations in brain development and neurodevelopmental disease risk may not only provide new insight into the pathophysiology of mental health disorders that have their origins in exposure to infection/immune activation during pregnancy but may also offer new therapeutic targets.
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作者：
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