Characterizing the Spectrum of Bladder Health and Lower Urinary Tract Symptoms (LUTS) Among Women: Results From the CARDIA Study.
Characterizing the Spectrum of Bladder Health and Lower Urinary Tract Symptoms (LUTS) Among Women: Results From the CARDIA Study.
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DOI：
10.1016/j.urology.2021.05.032
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发表时间：
2021-12
期刊：
影响因子：
2.1
通讯作者：
Lewis, Cora E.
中科院分区：
文献类型：
--
作者：
Markland, Alayne D.;Shan, Liang;Brady, Sonya S.;Schreiner, Pamela J.;Sidney, Stephen;Van den Eeden, Stephen K.;Lewis, Cora E.
为了使膀胱健康的新定义具有可操作性，我们在年轻成人冠状动脉风险发展（CARDIA）研究中检查了女性下尿路症状（LUTS）的分布及其影响，沿着相关因素。我们使用2005-2006年和2010-2011年之间收集的经验证的LUTS症状负担和影响量表进行聚类分析。我们进行了多项逻辑回归分析，以评估在调整协变量（人口统计学，产科/妇科，合并症）后的聚类之间的心血管因素（代谢综合征，心血管健康行为和炎症）。在CARDIA妇女中（中位年龄51岁，范围42-59岁），具有完整的LUTS数据（n = 1302），我们确定并比较了4个聚类组：报告没有或非常轻微症状且对健康无影响的女性（膀胱健康，44%，n = 569），与LUTS女性相比，对健康的负面影响从轻度（31%，n = 407），中度（20%，n = 259），重度（5%，n = 67）。BMI（kg/m2）每降低1分，轻度（OR 0.97，CI 0.95-0.99）、中度（OR 0.95，CI 0.93-0.98）和重度（OR 0.90，CI 0.88-0.94）LUTS群集组与膀胱健康组相比的成员资格比值更低。与患有代谢综合征的女性相比，没有代谢综合征的女性在轻度（OR 0.67，CI 0.45-0.99），中度（OR 0.51，CI 0.33-0.79）和重度（OR 0.48，CI 0.24-0.94）LUTS集群组中的成员资格比膀胱健康组低。五分之二的中年女性符合我们对膀胱健康的定义。女性的膀胱健康和心血管健康可能有共同的因素，包括较低的BMI和没有代谢综合征。
To operationalize a new definition for bladder health, we examined the distribution of lower urinary tract symptoms (LUTS) and impact, along with associated factors, among women in the Coronary Artery Risk Development in Young Adults (CARDIA) study. We performed cluster analyses using validated LUTS symptom burden and impact scales collected between 2005–2006 and 2010–2011. We performed multinomial logistic regression analyses to evaluate cardiovascular factors (metabolic syndrome, cardiovascular health behaviors, and inflammation) between clusters after adjusting for covariates (demographic, obstetric/gynecologic, comorbidities). Among CARDIA women (median age 51, range 42–59) with complete LUTS data (n = 1302), we identified and compared 4 cluster groups: women who reported no or very mild symptoms and no impact on well-being (bladder health, 44%, n = 569), versus women with LUTS and negative impact on well-being ranging from mild (31%, n = 407), moderate (20%, n = 259), to severe (5%, n = 67). With each 1-point lower BMI (kg/m2), odds of membership in mild (OR 0.97, CI 0.95–0.99), moderate (OR 0.95, CI 0.93–0.98), and severe (OR 0.90, CI 0.88–0.94) LUTS cluster groups versus the bladder health group were lower. Compared to women with metabolic syndrome, women without metabolic syndrome had lower odds of membership in mild (OR 0.67, CI 0.45–0.99), moderate (OR 0.51, CI 0.33–0.79), and severe (OR 0.48, CI 0.24–0.94) LUTS cluster groups versus the bladder health group. Two out of 5 midlife women met our definition of bladder health. Bladder health and cardiovascular health among women may share common factors, including lower BMI and the absence of metabolic syndrome.
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影响因子：
2
作者：
Ladanchuk, Todd;Kwak, Seojung;Moore, Kate H.
通讯作者：
Moore, Kate H.
影响因子：
1.8
作者：
Swenson, Carolyn W.;Kolenic, Giselle E.;DeLancey, John O.
通讯作者：
DeLancey, John O.
影响因子：
23.4
作者：
Irwin, Debra E.;Milsom, Ian;Abrams, Paul
通讯作者：
Abrams, Paul
DOI：
10.1097/gme.0000000000000609
发表时间：
2016-06-01
期刊：
MENOPAUSE-THE JOURNAL OF THE MENOPAUSE SOCIETY
影响因子：
--
作者：
Ebong, Imo A.;Schreiner, Pamela;Wellons, Mellissa
通讯作者：
Wellons, Mellissa
影响因子：
2.1
作者：
Scarpero, HM;Fiske, J;Nitti, VW
通讯作者：
Nitti, VW