Vitamin D, vitamin D binding protein gene polymorphisms, race and risk of incident stroke: the Atherosclerosis Risk in Communities (ARIC) study.
Vitamin D, vitamin D binding protein gene polymorphisms, race and risk of incident stroke: the Atherosclerosis Risk in Communities (ARIC) study.
复制标题
DOI：
10.1111/ene.12731
复制
发表时间：
2015-08
影响因子：
5.1
通讯作者：
Michos ED
中科院分区：
文献类型：
--
作者：
Schneider AL;Lutsey PL;Selvin E;Mosley TH;Sharrett AR;Carson KA;Post WS;Pankow JS;Folsom AR;Gottesman RF;Michos ED
通过血清25-羟基维生素D [25（OH）D]测量的低维生素D水平与中风风险增加相关。关于这种关联是否因种族或D结合蛋白（DBP）单核苷酸多态性（SNP）状态而异，目前知之甚少。我们的目的是描述25（OH）D水平和DBP SNP与卒中事件之间的关联和相互作用。据推测，低25（OH）D与中风风险的关联在具有与较高DBP水平相关的基因型的人中更强。在社区动脉粥样硬化风险（ARIC）研究（基线1990-1992，平均年龄57岁，57%女性，23%黑人）中，通过质谱法测量了12158名参与者的25（OH）D，并对他们进行了随访，直至2011年裁定卒中事件。对两个DBP SNPs（rs7041，rs 4588）进行基因分型。考克斯模型根据人口统计学/行为/社会经济因素进行调整。在平均20年的随访中，发生了804例中风事件。25（OH）D的最低五分位数（<17.2 ng/ml）与较高的卒中风险相关[风险比（HR）1.34（1.06-1.71）vs最高五分位数];这种相关性在种族之间相似（P相互作用0.60）。在25（OH）D < 17.2 ng/ml和rs7041 TG/GG [HR = 1.29（1.00-1.67）]与TT基因型[HR = 1.19（0.94-1.52）]（P相互作用0.28）或rs 4588 CA/AA [HR = 1.37（1.07-1.74）]对比CC基因型[HR = 1.14（0.91-1.41）]（P相互作用0.11）。低25（OH）D是中风的危险因素。具有低25（OH）D的人在遗传上倾向于高DBP（rs7041 G，rs 4588 A等位基因），因此具有较低的预测生物可利用25（OH）D，可能具有更大的中风风险，尽管我们的结果不是决定性的，应该被解释为假设生成。
Low vitamin D levels, measured by serum 25-hydroxyvitamin D [25(OH)D], are associated with increased stroke risk. Less is known about whether this association differs by race or D binding protein (DBP) single nucleotide polymorphism (SNP) status. Our objective was to characterize the associations of and interactions between 25(OH)D levels and DBP SNPs with incident stroke. It was hypothesized that associations of low 25(OH)D with stroke risk would be stronger amongst persons with genotypes associated with higher DBP levels. 25(OH)D was measured by mass spectroscopy in 12 158 participants in the Atherosclerosis Risk in Communities (ARIC) study (baseline 1990–1992, mean age 57 years, 57% female, 23% black) and they were followed through 2011 for adjudicated stroke events. Two DBP SNPs (rs7041, rs4588) were genotyped. Cox models were adjusted for demographic/behavioral/socioeconomic factors. During a median of 20 years follow-up, 804 incident strokes occurred. The lowest quintile of 25(OH)D (<17.2 ng/ml) was associated with higher stroke risk [hazard ratio (HR) 1.34 (1.06–1.71) versus highest quintile]; this association was similar by race (P interaction 0.60). There was weak evidence of increased risk of stroke amongst those with 25(OH)D < 17.2 ng/ml and either rs7041 TG/GG [HR = 1.29 (1.00–1.67)] versus TT genotype [HR = 1.19 (0.94–1.52)] (P interaction 0.28) or rs4588 CA/AA [HR = 1.37 (1.07–1.74)] versus CC genotype [HR = 1.14 (0.91–1.41)] (P interaction 0.11). Low 25(OH)D is a risk factor for stroke. Persons with low 25 (OH)D who are genetically predisposed to high DBP (rs7041 G, rs4588 A alleles), who therefore have lower predicted bioavailable 25(OH)D, may be at greater risk for stroke, although our results were not conclusive and should be interpreted as hypothesis generating.
登录
查看更多内容
影响因子：
8.3
作者：
Rosamond, WD;Folsom, AR;Shahar, E
通讯作者：
Shahar, E
影响因子：
5.3
作者：
Pugliese, Giuseppe;Solini, Anna;Penno, Giuseppe
通讯作者：
Penno, Giuseppe
影响因子：
19.6
作者：
通讯作者：
--
影响因子：
7.1
作者：
Reis, Jared P.;Michos, Erin D.;Miller, Edgar R., III
通讯作者：
Miller, Edgar R., III
DOI：
10.1161/circgenetics.109.882696
发表时间：
2010-06
期刊：
Circulation. Cardiovascular genetics
影响因子：
--
作者：
Musunuru K;Lettre G;Young T;Farlow DN;Pirruccello JP;Ejebe KG;Keating BJ;Yang Q;Chen MH;Lapchyk N;Crenshaw A;Ziaugra L;Rachupka A;Benjamin EJ;Cupples LA;Fornage M;Fox ER;Heckbert SR;Hirschhorn JN;Newton-Cheh C;Nizzari MM;Paltoo DN;Papanicolaou GJ;Patel SR;Psaty BM;Rader DJ;Redline S;Rich SS;Rotter JI;Taylor HA Jr;Tracy RP;Vasan RS;Wilson JG;Kathiresan S;Fabsitz RR;Boerwinkle E;Gabriel SB;NHLBI Candidate Gene Association Resource
通讯作者：
NHLBI Candidate Gene Association Resource