Aflatoxin Exposure during Early Life Is Associated with Differential DNA Methylation in Two-Year-Old Gambian Children.
Aflatoxin Exposure during Early Life Is Associated with Differential DNA Methylation in Two-Year-Old Gambian Children.
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早期生命中的黄曲霉毒素暴露与2岁冈比亚儿童的差异DNA甲基化有关。
DOI：
10.3390/ijms22168967
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发表时间：
2021-08-20
影响因子：
5.6
通讯作者：
Routledge MN
中科院分区：
文献类型：
--
作者：
Ghantous A;Novoloaca A;Bouaoun L;Cuenin C;Cros MP;Xu Y;Hernandez-Vargas H;Darboe MK;Prentice AM;Moore SE;Gong YY;Herceg Z;Routledge MN
Background: DNA methylation is an epigenetic control mechanism that may be altered by environmental exposures. We have previously reported that in utero exposure to the mycotoxin and liver carcinogen aflatoxin B1 from the maternal diet, as measured using biomarkers in the mothers’ blood, was associated with differential DNA methylation in white blood cells of 6-month-old infants from The Gambia. Methods: Here we examined aflatoxin B1-associated differential DNA methylation in white blood cells of 24-month-old children from the same population (n = 244), in relation to the child’s dietary exposure assessed using aflatoxin albumin biomarkers in blood samples collected at 6, 12 and 18 months of age. HM450 BeadChip arrays were used to assess DNA methylation, with data compared to aflatoxin albumin adduct levels using two approaches; a continuous model comparing aflatoxin adducts measured in samples collected at 18 months to DNA methylation at 24 months, and a categorical time-dose model that took into account aflatoxin adduct levels at 6, 12 and 18 months, for comparison to DNA methylation at 24 months. Results: Geometric mean (95% confidence intervals) for aflatoxin albumin levels were 3.78 (3.29, 4.34) at 6 months, 25.1 (21.67, 29.13) at 12 months and 49.48 (43.34, 56.49) at 18 months of age. A number of differentially methylated CpG positions and regions were associated with aflatoxin exposure, some of which affected gene expression. Pathway analysis highlighted effects on genes involved with with inflammatory, signalling and growth pathways. Conclusions: This study provides further evidence that exposure to aflatoxin in early childhood may impact on DNA methylation.
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通讯作者：
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影响因子：
10.4
作者：
Gong Y;Hounsa A;Egal S;Turner PC;Sutcliffe AE;Hall AJ;Cardwell K;Wild CP
通讯作者：
Wild CP