Postweaning exposure to aflatoxin results in impaired child growth: a longitudinal study in Benin, West Africa.
Postweaning exposure to aflatoxin results in impaired child growth: a longitudinal study in Benin, West Africa.
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节外后暴露于黄曲霉毒素会导致儿童成长受损：西非贝宁的一项纵向研究。
DOI：
10.1289/ehp.6954
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发表时间：
2004-09
影响因子：
10.4
通讯作者：
Wild CP
中科院分区：
文献类型：
--
作者：
Gong Y;Hounsa A;Egal S;Turner PC;Sutcliffe AE;Hall AJ;Cardwell K;Wild CP
黄曲霉毒素是一种饮食污染物，具有致癌和免疫毒性，可导致动物生长迟缓，但在暴露于人群中有关后两种参数的证据很少。众所周知，西非儿童接触黄曲霉毒素的程度很高，因此我们在贝宁进行了一项为期8个月的纵向研究，以评估接触黄曲霉毒素对生长的影响。从四个村庄招募了200名16-37个月大的儿童，其中两个高黄曲霉毒素暴露，两个低黄曲霉毒素暴露(每个村庄50名儿童)。在招募时(2月)和随后的两个时间点(6月和10月)测量了血清黄曲霉毒素-白蛋白(AF-Alb)加合物、人体测量参数、食物消费信息和各种人口统计数据。同时测定血浆维生素A和锌水平。在2月至10月期间，四个村庄中的三个村庄的AF-Alb加合物显著增加，在暴露水平较高的村庄增加幅度最大。在招募时完全断奶的儿童比那些仍然部分母乳喂养的儿童的AF-Alb更高(P<；0.0001)；主要的断奶食物是以玉米为基础的粥。房颤-白蛋白和微量营养素水平之间没有关联，这表明接触黄曲霉毒素并不伴随着普遍的营养缺乏。然而，在调整了年龄、性别、招募时的身高、社会经济地位、村庄和断奶状态后，在8个月的随访中，AF-Alb与身高增长之间存在强烈的负相关(p<；0.0001)；与最低的四分之一相比，AF-Alb的最高四分位数与8个月后平均减少1.7cm.这项研究强调黄曲霉毒素和发育迟缓之间的联系，尽管潜在的机制尚不清楚。在断奶期间接触黄曲霉毒素对西非儿童的健康有害影响可能是至关重要的，减少接触的干预措施值得调查。
Aflatoxins are dietary contaminants that are hepatocarcinogenic and immunotoxic and cause growth retardation in animals, but there is little evidence concerning the latter two parameters in exposed human populations. Aflatoxin exposure of West African children is known to be high, so we conducted a longitudinal study over an 8-month period in Benin to assess the effects of exposure on growth. Two hundred children 16–37 months of age were recruited from four villages, two with high and two with low aflatoxin exposure (50 children per village). Serum aflatoxin–albumin (AF-alb) adducts, anthropometric parameters, information on food consumption, and various demographic data were measured at recruitment (February) and at two subsequent time points (June and October). Plasma levels of vitamin A and zinc were also measured. AF-alb adducts increased markedly between February and October in three of the four villages, with the largest increases in the villages with higher exposures. Children who were fully weaned at recruitment had higher AF-alb than did those still partially breast-fed (p < 0.0001); the major weaning food was a maize-based porridge. There was no association between AF-alb and micronutrient levels, suggesting that aflatoxin exposure was not accompanied by a general nutritional deficiency. There was, however, a strong negative correlation (p < 0.0001) between AF-alb and height increase over the 8-month follow-up after adjustment for age, sex, height at recruitment, socioeconomic status, village, and weaning status; the highest quartile of AF-alb was associated with a mean 1.7 cm reduction in growth over 8 months compared with the lowest quartile. This study emphasizes the association between aflatoxin and stunting, although the underlying mechanisms remain unclear. Aflatoxin exposure during the weaning period may be critical in terms of adverse health effects in West African children, and intervention measures to reduce exposure merit investigation.
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影响因子：
2.7
作者：
Hell, K;Cardwell, KF;Poehling, HM
通讯作者：
Poehling, HM
影响因子：
4.1
作者：
Turner, PC;Sylla, A;Wild, CP
通讯作者：
Wild, CP
DOI：
10.1016/s1383-5742(00)00027-2
发表时间：
2000-04-01
影响因子：
5.3
作者：
Wild, CP;Hall, AJ
通讯作者：
Hall, AJ
影响因子：
5.5
作者：
RAISUDDIN, S;SINGH, KP;RAY, PK
通讯作者：
RAY, PK
影响因子：
--
作者：
Gong, YY;Cardwell, K;Wild, CP
通讯作者：
Wild, CP