Teratopyrones A-C, Dimeric Naphtho-γ-Pyrones and Other Metabolites from Teratosphaeria sp. AK1128, a Fungal Endophyte of Equisetum arvense.
Teratopyrones A-C, Dimeric Naphtho-γ-Pyrones and Other Metabolites from Teratosphaeria sp. AK1128, a Fungal Endophyte of Equisetum arvense.
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DOI：
10.3390/molecules25215058
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发表时间：
2020-10-30
期刊：
影响因子：
--
通讯作者：
Gunatilaka AAL
中科院分区：
文献类型：
--
作者：
Xu YM;Arnold AE;U Ren JM;Xuan LJ;Wang WQ;Gunatilaka AAL
用生物测定法对马铃薯固体葡萄糖琼脂培养物Teratosphaeria sp. AK1128的细胞毒性萃取物进行分离，得到三种新的萘环-γ-pyrone二聚体，teratopyrones a - C(1-3)，以及五种已知的萘环-γ-pyrone， aurasperone B (4), aurasperone C (5), aurasperone F (6), nigerasperone a(7)和fonsecin B(8)，以及两种已知的双酮哌嗪，asperazine(9)和isoruglosuvine（10）。根据它们的光谱数据确定了1-3的结构。细胞毒实验结果显示，奈格斯波龙A(7)对PC-3M（人转移性前列腺癌）、NCI-H460（人非小细胞肺癌）、SF-268（人中枢神经胶质瘤）和MCF-7（人乳腺癌）具有中等活性，ic50值在2.37 ~ 4.12 μM之间，而其他代谢物在5.0 μM浓度下无细胞毒活性。
Bioassay-guided fractionation of a cytotoxic extract derived from a solid potato dextrose agar (PDA) culture of Teratosphaeria sp. AK1128, a fungal endophyte of Equisetum arvense, afforded three new naphtho-γ-pyrone dimers, teratopyrones A–C (1–3), together with five known naphtho-γ-pyrones, aurasperone B (4), aurasperone C (5), aurasperone F (6), nigerasperone A (7), and fonsecin B (8), and two known diketopiperazines, asperazine (9) and isorugulosuvine (10). The structures of 1–3 were determined on the basis of their spectroscopic data. Cytotoxicity assay revealed that nigerasperone A (7) was moderately active against the cancer cell lines PC-3M (human metastatic prostate cancer), NCI-H460 (human non-small cell lung cancer), SF-268 (human CNS glioma), and MCF-7 (human breast cancer), with IC50s ranging from 2.37 to 4.12 μM while other metabolites exhibited no cytotoxic activity up to a concentration of 5.0 μM.
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影响因子：
5.8
作者：
Posada, D;Crandall, KA
通讯作者：
Crandall, KA
影响因子：
5.1
作者：
Wijeratne EM;Gunaherath GM;Chapla VM;Tillotson J;de la Cruz F;Kang M;U'Ren JM;Araujo AR;Arnold AE;Chapman E;Gunatilaka AA
通讯作者：
Gunatilaka AA
影响因子：
2.1
作者：
PRIESTAP, HA
通讯作者：
PRIESTAP, HA
影响因子：
3.7
作者：
Higginbotham SJ;Arnold AE;Ibañez A;Spadafora C;Coley PD;Kursar TA
通讯作者：
Kursar TA
影响因子：
2.2
作者：
Siriwardane, A. M. D. A.;Kumar, N. Savitri;Fujimoto, Yoshinori
通讯作者：
Fujimoto, Yoshinori