Dietary Isoflavone-Dependent and Estradiol Replacement Effects on Body Weight in the Ovariectomized (OVX) Rat.
Dietary Isoflavone-Dependent and Estradiol Replacement Effects on Body Weight in the Ovariectomized (OVX) Rat.
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DOI：
10.1055/s-0043-108250
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发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Larco DO
中科院分区：
文献类型：
--
作者：
Russell AL;Grimes JM;Cruthirds DF;Westerfield J;Wooten L;Keil M;Weiser MJ;Landauer MR;Handa RJ;Wu TJ;Larco DO
已知 17β-雌二醇可调节能量代谢和体重。卵巢切除术会导致体重增加，而雌二醇给药则会导致体重增加逆转。在啮齿动物食物中发现的异黄酮可以模仿雌激素的作用，因此了解这些化合物在代谢调节中的作用至关重要。本研究的目的是检查膳食异黄酮对卵巢切除大鼠体重调节的影响。这项研究将探讨膳食异黄酮如何与雌二醇治疗相互作用以影响体重。与之前的研究结果一致，与饲喂不含异黄酮饮食的动物相比，饲喂富含异黄酮饮食的动物体重（p < 0.05）、腹部脂肪（p < 0.05）和血清瘦素水平（p < 0.05）降低。雌二醇替代导致体重（p < 0.05）、腹部脂肪（p < 0.05）和血清瘦素（p < 0.05）下降。目前的文献表明细胞因子参与体重增加的炎症反应。我们筛选了许多可能被膳食异黄酮或雌二醇替代品改变的细胞因子和趋化因子。血清细胞因子分析显示，饮食依赖性炎症细胞因子（角质形成细胞衍生的趋化因子）显着增加（p < 0.05）。 OVX 大鼠的无异黄酮饮食导致以下细胞因子和趋化因子的调节：白细胞介素 10、白细胞介素 18、激活调节的血清、正常 T 细胞表达和分泌以及单核细胞趋化蛋白 1 (p < 0.05)。总体而言，这些结果表明，雌二醇治疗可能对能量代谢和体重调节产生不同的影响，具体取决于啮齿动物食物中异黄酮的存在。
17β-Estradiol is known to regulate energy metabolism and body weight. Ovariectomy results in body weight gain while estradiol administration results in a reversal of weight gain. Isoflavones, found in rodent chow, can mimic estrogenic effects making it crucial to understand the role of these compounds on metabolic regulation. The goal of this study is to examine the effect of dietary isoflavones on body weight regulation in the ovariectomized rat. This study will examine how dietary isoflavones can interact with estradiol treatment to affect body weight. Consistent with previous findings, animals fed an isoflavone-rich diet had decreased body weight (p < 0.05), abdominal fat (p < 0.05), and serum leptin levels (p < 0.05) compared to animals fed an isoflavone-free diet. Estradiol replacement resulted in decreased body weight (p < 0.05), abdominal fat (p < 0.05), and serum leptin (p < 0.05). Current literature suggests the involvement of cytokines in the inflammatory response of body weight gain. We screened a host of cytokines and chemokines that may be altered by dietary isoflavones or estradiol replacement. Serum cytokine analysis revealed significant (p < 0.05) diet-dependent increases in inflammatory cytokines (keratinocyte-derived chemokine). The isoflavone-free diet in OVX rats resulted in the regulation of the following cytokines and chemokines: interleukin-10, interleukin-18, serum regulated on activation, normal T cell expressed and secreted, and monocyte chemoattractant protein-1 (p < 0.05). Overall, these results reveal that estradiol treatment can have differential effects on energy metabolism and body weight regulation depending on the presence of isoflavones in rodent chow.
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影响因子：
3.4
作者：
Hartley, DE;Edwards, JE;File, SE
通讯作者：
File, SE
影响因子：
7
作者：
Coppack, SW
通讯作者：
Coppack, SW
影响因子：
4.8
作者：
Brown, Candice M.;Mulcahey, Tara A.;Wise, Phyllis M.
通讯作者：
Wise, Phyllis M.
影响因子：
4.1
作者：
Cooke, PS;Heine, PA;Lubahn, DB
通讯作者：
Lubahn, DB
影响因子：
4.8
作者：
Esposito, E;Iacono, A;Meli, R
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Meli, R