Lifestyle and Clinical Risk Factors for Incident Rheumatoid Arthritis-associated Interstitial Lung Disease.
Lifestyle and Clinical Risk Factors for Incident Rheumatoid Arthritis-associated Interstitial Lung Disease.
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DOI：
10.3899/jrheum.200863
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Sparks JA
中科院分区：
文献类型：
--
作者：
Kronzer VL;Huang W;Dellaripa PF;Huang S;Feathers V;Lu B;Iannaccone CK;Gill RR;Hatabu H;Nishino M;Crowson CS;Davis JM 3rd;Weinblatt ME;Shadick NA;Doyle TJ;Sparks JA
为了确定新的生活方式因素与类风湿关节炎相关间质性肺疾病（RA-ILD）风险之间的关系，定义吸烟增加RA-ILD风险的阈值，并计算已知生活方式和临床因素预测RA-ILD的程度。该巢式病例对照研究在年龄、性别、RA病程、类风湿因子和从暴露评估到RA- ild的时间方面将RA- ild病例与RA非ild对照进行匹配。暴露包括教育程度、体重指数（BMI）、吸烟、抗环瓜氨酸肽、种族、关节糜烂、类风湿结节、c反应蛋白（CRP）、疾病活动评分、功能状态、改善疾病的抗风湿药物使用和糖皮质激素使用。通过logistic回归模型获得每次暴露对RA-ILD风险的比值比（OR）。曲线下面积（AUC）是基于所有生活方式和临床暴露来计算的。我们确定了84例RA-ILD病例和233例匹配对照。调整后，肥胖、高阳性CRP（≥10mg /L）和功能状态差（MDHAQ≥1）与RA-ILD风险增加相关（与正常BMI相比，OR为2.42,95%可信区间[CI] 1.11-5.24；与CRP <3mg/L相比，OR为2.61,95% CI为1.21-5.64；与MDHAQ <0.2相比，OR为3.10,95% CI为1.32-7.26）。与不吸烟者相比，吸烟30包年或以上与RA-ILD的风险密切相关（or 6.06, 95% CI 2.72-13.5）。生活方式和RA-ILD的临床危险因素合计AUC为0.79 （95% CI 0.73-0.85）。肥胖、CRP、功能状态和广泛吸烟可能是RA-ILD的新危险因素，有助于RA-ILD风险评估和预防。预测RA-ILD的总体能力仍然不高。
To determine the association between novel lifestyle factors on risk of rheumatoid arthritis-associated interstitial lung disease (RA-ILD), define the threshold at which smoking increases RA-ILD risk, and calculate the degree to which known lifestyle and clinical factors predict RA-ILD. This nested case-control study matched incident RA-ILD cases to RA non-ILD controls on age, sex, RA duration, rheumatoid factor, and time from exposure assessment to RA-ILD. Exposures included education, body mass index (BMI), smoking, anti-cyclic citrullinated peptide, race, joint erosions, rheumatoid nodules, C-reactive protein (CRP), disease activity score, functional status, disease-modifying anti-rheumatic drug use, and glucocorticoid use. Odds ratios (OR) for each exposure on risk of RA-ILD were obtained from logistic regression models. Area under the curve (AUC) was calculated based all lifestyle and clinical exposures. We identified 84 incident RA-ILD cases and 233 matched controls. After adjustment, obesity, high-positive CRP (≥10 mg/L), and poor functional status (MDHAQ ≥1) were associated with increased risk of RA-ILD (OR 2.42, 95% confidence interval [CI] 1.11–5.24 vs. normal BMI; OR 2.61, 95% CI 1.21–5.64 vs. CRP <3mg/L; OR 3.10, 95% CI 1.32–7.26 vs. MDHAQ <0.2). Smoking 30 pack-years or more was strongly associated with risk of RA-ILD compared to nonsmokers (OR 6.06, 95% CI 2.72–13.5). Together, lifestyle and clinical risk factors for RA-ILD had an AUC of 0.79 (95% CI 0.73–0.85). Obesity, CRP, functional status, and extensive smoking may be novel risk factors for RA-ILD, useful for RA-ILD risk assessment and prevention. The overall ability to predict RA-ILD remains modest.
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影响因子：
4.7
作者：
Crowson, Cynthia S.;Matteson, Eric L.;Davis, John M.;Gabriel, Sherine E.
通讯作者：
Gabriel, Sherine E.
DOI：
10.1056/nejmoa1801562
发表时间：
2018-12-06
期刊：
The New England journal of medicine
影响因子：
--
作者：
Juge PA;Lee JS;Ebstein E;Furukawa H;Dobrinskikh E;Gazal S;Kannengiesser C;Ottaviani S;Oka S;Tohma S;Tsuchiya N;Rojas-Serrano J;González-Pérez MI;Mejía M;Buendía-Roldán I;Falfán-Valencia R;Ambrocio-Ortiz E;Manali E;Papiris SA;Karageorgas T;Boumpas D;Antoniou K;van Moorsel CHM;van der Vis J;de Man YA;Grutters JC;Wang Y;Borie R;Wemeau-Stervinou L;Wallaert B;Flipo RM;Nunes H;Valeyre D;Saidenberg-Kermanac'h N;Boissier MC;Marchand-Adam S;Frazier A;Richette P;Allanore Y;Sibilia J;Dromer C;Richez C;Schaeverbeke T;Lioté H;Thabut G;Nathan N;Amselem S;Soubrier M;Cottin V;Clément A;Deane K;Walts AD;Fingerlin T;Fischer A;Ryu JH;Matteson EL;Niewold TB;Assayag D;Gross A;Wolters P;Schwarz MI;Holers M;Solomon JJ;Doyle T;Rosas IO;Blauwendraat C;Nalls MA;Debray MP;Boileau C;Crestani B;Schwartz DA;Dieudé P
通讯作者：
Dieudé P
影响因子：
3.1
作者：
Choi WI;Dauti S;Kim HJ;Park SH;Park JS;Lee CW
通讯作者：
Lee CW
影响因子：
4
作者：
Kim, Dam;Cho, Soo-Kyung;Sung, Yoon-Kyoung
通讯作者：
Sung, Yoon-Kyoung
影响因子：
4.9
作者：
Di Giuseppe D;Discacciati A;Orsini N;Wolk A
通讯作者：
Wolk A