Contribution of obesity to the rise in incidence of rheumatoid arthritis.
Contribution of obesity to the rise in incidence of rheumatoid arthritis.
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DOI：
10.1002/acr.21660
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发表时间：
2013-01
影响因子：
4.7
通讯作者：
Gabriel, Sherine E.
中科院分区：
文献类型：
--
作者：
Crowson, Cynthia S.;Matteson, Eric L.;Davis, John M.;Gabriel, Sherine E.
确定“肥胖流行病”是否可以解释最近类风湿关节炎发病率的上升。肥胖是RA的一个未被充分认识的危险因素。近年来，肥胖的患病率和类风湿关节炎的发病率均呈上升趋势。将1980-2007年符合1987年美国风湿病学会RA标准的明尼苏达州奥姆斯特德县居民的初始队列与基于人群的对照组（年龄，性别和日历年匹配）进行比较。从医疗记录中收集身高、体重和吸烟状况。肥胖定义为体重指数（BMI）≥ 30 kg/m2。采用条件Logistic回归分析肥胖对RA发生的影响。人群归因危险度被用来估计在没有肥胖的情况下类风湿关节炎的发病率。该研究包括813名RA患者和813名对照。两组在发生/索引日期之前都有广泛的病史（平均32.2年），在发生/索引日期时每组约有30%的患者肥胖。肥胖史与发生RA显著相关（OR：1.24; 95%CI：1.01，1.53，经吸烟状态调整）。1985-2007年，女性类风湿关节炎发病率增加了每10万人9.2例。肥胖占这一增长的4.8/10万（或52%）。肥胖与发生类风湿关节炎的适度风险有关。鉴于肥胖的患病率迅速增加，这对RA发病率产生了重大影响，并可能是最近RA发病率增加的主要原因。
To determine whether the “obesity epidemic” could explain the recent rise in the incidence of RA. Obesity is an under-recognized risk factor for RA. In recent years both the prevalence of obesity and the incidence of RA have been rising. An inception cohort of Olmsted County, Minnesota residents who fulfilled 1987 American College of Rheumatology criteria for RA in 1980–2007 was compared to population-based controls (matched on age, sex and calendar year). Heights, weights and smoking status were collected from medical records. Obesity was defined as body mass index (BMI) ≥ 30 kg/m2. Conditional logistic regression was used to assess the influence of obesity on developing RA. Population attributable risk was used to estimate the incidence of RA in the absence of obesity. The study included 813 patients with RA and 813 controls. Both groups had extensive medical history available prior to incidence/index date (mean 32.2 years), and approximately 30% of each group were obese at incidence/index date. The history of obesity was a significantly associated with developing RA (OR:1.24; 95 % CI: 1.01, 1.53 adjusted for smoking status). In 1985–2007 the incidence of RA rose by an increment of 9.2 per 100,000 among women. Obesity accounted for 4.8 per 100,000 (or 52%) of this increase. Obesity is associated with a modest risk for developing RA. Given the rapidly increasing prevalence of obesity, this has had a significant impact on RA incidence and may account for much of the recent increase in incidence of RA.
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影响因子：
120.7
作者：
Flegal, Katherine M.;Carroll, Margaret D.;Curtin, Lester R.
通讯作者：
Curtin, Lester R.
影响因子：
--
作者：
Myasoedova, Elena;Crowson, Cynthia S.;Kremers, Hilal Maradit;Therneau, Terry M.;Gabriel, Sherine E.
通讯作者：
Gabriel, Sherine E.
DOI：
10.1097/gme.0b013e31802cddca
发表时间：
2007-09-01
影响因子：
2.7
作者：
Hong, Soon Cheol;Yoo, Sang Wook;Kim, Sun Haeng
通讯作者：
Kim, Sun Haeng
影响因子：
--
作者：
Merlino, LA;Curtis, J;Saag, KG
通讯作者：
Saag, KG
影响因子：
6.9
作者：
McTiernan, Anne;Wu, LieLing;Wang, C. Y.
通讯作者：
Wang, C. Y.