Differential selective pressures on the merozoite surface protein 2 locus of Plasmodium falciparum in a low endemic area.
Differential selective pressures on the merozoite surface protein 2 locus of Plasmodium falciparum in a low endemic area.
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DOI：
10.1016/j.gene.2008.09.009
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发表时间：
2008-12-31
期刊：
影响因子：
3.5
通讯作者：
Hughes, Austin L.
中科院分区：
文献类型：
--
作者：
Putaporntip, Chaturong;Jongwutiwes, Somchai;Hughes, Austin L.
1996年和2006年在泰国Tak省收集的195个恶性疟原虫裂殖子表面蛋白-2等位基因显示出除可变区（V）外极其有限的序列多态性，该可变区定义了两个等位基因家族3D 7和FC 27。这种模式是最容易解释的重复等位基因间的基因转换事件的V区以外的等位基因。等位基因家族内V区的同义和非同义差异的比较支持这一假设，即在该地区的氨基酸序列多态性是选择性的青睐。序列分化的模式支持的假设，在V区的重复已经通过协同进化的3D 7家庭，而不是在FC 27家庭。在FC 27家族中，两个相对高频率的等位基因是1996年和2006年最常见的V区等位基因，而3D 7等位基因在2006年收集的序列中所占的比例（56.1%）显著高于1996年收集的序列（28.9%）。3D 7等位基因频率的这些变化可能反映了泰国恶性疟原虫种群选择强度的增加，这是由于有效的控制措施大大降低了疟疾感染的发病率。
195 Plasmodium falciparum merozoite surface protein-2 alleles collected in Tak Province, Thailand, in 1996 and 2006 revealed extremely limited sequence polymorphism except in the variable (V) region, which defines the two allelic families 3D7 and FC27. This pattern is most easily explained by repeated inter-allelic gene conversion events homogenizing alleles outside the V region. Comparison of synonymous and nonsynonymous differences in V regions within allelic families supported the hypothesis that amino acid sequence polymorphism in this region is selectively favored. The pattern of sequence differentiation supported the hypothesis that repeats in the V region have evolved by concerted evolution in the 3D7 family but not in the FC27 family. In the FC27 family two alleles of relatively high frequency were the most common V-region alleles in both 1996 and 2006, while 3D7 alleles constituted a significantly greater proportion of the sequences collected in 2006 (56.1%) than of those collected in 1996 (28.9%). These changes in the frequencies of 3D7 alleles may reflect increased intensity of selection on the P. falciparum population in Thailand as a result of effective control measures that have sharply reduced the incidence of malaria infection.
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