Estrogen weakens muscle endurance via estrogen receptor-p38 MAPK-mediated orosomucoid (ORM) suppression.
Estrogen weakens muscle endurance via estrogen receptor-p38 MAPK-mediated orosomucoid (ORM) suppression.
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雌激素通过雌激素受体-p38 MAPK 介导的口腔类粘蛋白 (ORM) 抑制削弱肌肉耐力
DOI：
10.1038/emm.2017.307
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发表时间：
2018-03-30
影响因子：
12.8
通讯作者：
Liu X
中科院分区：
文献类型：
--
作者：
Sun Y;Qin Z;Wan JJ;Wang PY;Yang YL;Yu JG;Hu BH;Su DF;Luo ZM;Liu X
疲劳的性别差异表现为女性更容易感到疲惫，肌肉耐力较低。然而，这些影响的机制仍不清楚。我们研究了是否orosomucoid，一种内源性抗疲劳蛋白，提高肌肉耐力，参与这种调节。雌性大鼠表现出较低的肌肉耐力，这种性别差异在orosomucoid-1缺陷小鼠中消失。雌性大鼠也表现出较弱的orosomucoid诱导在血清中，肝脏和肌肉疲劳的反应相比，雄性大鼠。卵巢切除术升高血清类粘蛋白水平，增加游泳时间，雌激素补充逆转这些影响。外源性雌激素治疗雄性和雌性小鼠产生相反的效果。雌激素降低C2C12肌细胞和Chang肝细胞的orosomucoid表达及其启动子活性，雌激素受体或p38丝裂原活化蛋白激酶阻断剂可消除这种作用。因此，雌激素负调节orosomucoid表达，这是负责较弱的肌肉耐力在女性。
Gender differences in fatigue manifest as females being more prone to feel exhaustion and having lower muscle endurance. However, the mechanisms of these effects remain unclear. We investigated whether orosomucoid, an endogenous anti-fatigue protein that enhances muscle endurance, is involved in this regulation. Female rats exhibited lower muscle endurance, and this gender difference disappeared in orosomucoid-1-deficient mice. Female rats also exhibited weaker orosomucoid induction in serum, liver and muscle in response to fatigue compared with male rats. Ovariectomy elevated orosomucoid levels and increased swimming time, and estrogen replenishment reversed these effects. Exogenous estrogen treatment in male and female mice produced opposite effects. Estrogen decreased orosomucoid expression and its promoter activity in C2C12 muscle and Chang liver cells in vitro, and estrogen receptor or p38 mitogen-activated protein kinase blockade abolished this effect. Therefore, estrogen negatively regulates orosomucoid expression that is responsible for the weaker muscle endurance in females.
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影响因子：
3.3
作者：
Clark, BC;Manini, TM;Ploutz-Snyder, LL
通讯作者：
Ploutz-Snyder, LL
DOI：
10.2170/jjphysiol.51.753
发表时间：
2001-12-01
期刊：
JAPANESE JOURNAL OF PHYSIOLOGY
影响因子：
--
作者：
Hatae, J
通讯作者：
Hatae, J
影响因子：
4.3
作者：
BrinkmanVanderLinden, ECM;Havenaar, EC;VanDijk, W
通讯作者：
VanDijk, W
影响因子：
3.8
作者：
Doymaz, Fadime;Cavlak, Ugur
通讯作者：
Cavlak, Ugur
影响因子：
--
作者：
Bianco A;Lupo C;Alesi M;Spina S;Raccuglia M;Thomas E;Paoli A;Palma A
通讯作者：
Palma A