Skin and Gut Microbiome in Psoriasis: Gaining Insight Into the Pathophysiology of It and Finding Novel Therapeutic Strategies.
Skin and Gut Microbiome in Psoriasis: Gaining Insight Into the Pathophysiology of It and Finding Novel Therapeutic Strategies.
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DOI：
10.3389/fmicb.2020.589726
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发表时间：
2020
影响因子：
5.2
通讯作者：
Peng C
中科院分区：
文献类型：
--
作者：
Chen L;Li J;Zhu W;Kuang Y;Liu T;Zhang W;Chen X;Peng C
牛皮癣影响着世界各地无数人口的健康。发病机制是多因素的，确切的驱动因素尚不清楚。这种情况是由于过度增殖的角质形成细胞和浸润性免疫细胞之间的相互作用引起的，预后差，复发率高。更好的临床治疗方法仍有待探索。大量证据表明，皮肤和肠道微生物群的改变在银屑病的发病机制中起着重要作用，而微生物群的修复是银屑病一种有前途的预防和治疗策略。在此，我们对近年来关于银屑病相关微生物群的研究进行综述，以期确定银屑病患者的核心微生物群，了解微生物群在银屑病发病机制中的作用，并通过微生物干预探索银屑病的新治疗策略。
Psoriasis affects the health of myriad populations around the world. The pathogenesis is multifactorial, and the exact driving factor remains unclear. This condition arises from the interaction between hyperproliferative keratinocytes and infiltrating immune cells, with poor prognosis and high recurrence. Better clinical treatments remain to be explored. There is much evidence that alterations in the skin and intestinal microbiome play an important role in the pathogenesis of psoriasis, and restoration of the microbiome is a promising preventive and therapeutic strategy for psoriasis. Herein, we have reviewed recent studies on the psoriasis-related microbiome in an attempt to confidently identify the “core” microbiome of psoriasis patients, understand the role of microbiome in the pathogenesis of psoriasis, and explore new therapeutic strategies for psoriasis through microbial intervention.
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影响因子：
32.4
作者：
Bunker JJ;Flynn TM;Koval JC;Shaw DG;Meisel M;McDonald BD;Ishizuka IE;Dent AL;Wilson PC;Jabri B;Antonopoulos DA;Bendelac A
通讯作者：
Bendelac A
影响因子：
4.6
作者：
Codoñer FM;Ramírez-Bosca A;Climent E;Carrión-Gutierrez M;Guerrero M;Pérez-Orquín JM;Horga de la Parte J;Genovés S;Ramón D;Navarro-López V;Chenoll E
通讯作者：
Chenoll E
影响因子：
3.6
作者：
Chen, Yi-Ju;Ho, Hsiu J.;Wu, Chun-Ying
通讯作者：
Wu, Chun-Ying
影响因子：
24.5
作者：
Camilleri, Michael
通讯作者：
Camilleri, Michael
影响因子：
14.9
作者：
Claesson MJ;Wang Q;O'Sullivan O;Greene-Diniz R;Cole JR;Ross RP;O'Toole PW
通讯作者：
O'Toole PW