Simulation of platelet, thrombus and erythrocyte hydrodynamic interactions in a 3D arteriole with in vivo comparison.
Simulation of platelet, thrombus and erythrocyte hydrodynamic interactions in a 3D arteriole with in vivo comparison.
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DOI：
10.1371/journal.pone.0076949
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
King MR
中科院分区：
文献类型：
--
作者：
Wang W;Diacovo TG;Chen J;Freund JB;King MR
圆柱形血管、椭圆形血小板和双凹形可变形红细胞（RBC）是止血和血栓形成的重要参与者。然而，由于在仿真工具中组合这些组件的挑战，很少有仿真研究将所有这些组件包含在现实的三维模型中。在本研究中，我们应用最近开发的模拟模型来合并这些组件并分析血栓性管状小动脉中的流动，特别是血栓形状、红细胞和血小板之间的详细流体动力学相互作用。研究发现，在某些方位位置，血栓上游和下游边缘附近的速度下降，同时狭窄区域的速度迅速增加。红细胞显着改变了典型的低雷诺 (Re) 数血流的血流分布，并且还增强了自由流动的血小板在血栓上的沉积。通过一起评估血小板-血栓相互作用和血小板-红细胞相互作用，确定了血小板沉积增加的几种机制。通过体内数据比较，我们的模型说明了未来血栓形成研究纳入详细的受体-配体粘附模块的潜力。
Cylindrical blood vessels, ellipsoid platelets and biconcave-shaped deformable erythrocytes (RBCs) are important participants in hemostasis and thrombosis. However, due to the challenge of combining these components in simulation tools, few simulation studies have included all of them in realistic three-dimensional models. In the present study, we apply a recently developed simulation model to incorporate these components and analyze the flow in a thrombotic tubular arteriole, particularly the detailed hydrodynamic interactions between the thrombus shape, RBCs and platelets. It was found that at certain azimuth positions, the velocity drops in the proximity of both the upstream and downstream edge of the thrombus, which is accompanied by a rapid velocity increase in the narrowed region. The RBCs alter the flow profiles significantly from the typical low Reynolds (Re) number flow, and also enhance the deposition of free flowing platelets onto the thrombus. By evaluating the platelet-thrombus interaction and platelet-RBC interaction together, several mechanisms of platelet deposition augmentation are identified. With in vivo data comparison, our model illustrates the potential of future thrombosis studies that incorporate detailed receptor-ligand adhesion modules.
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影响因子：
2.9
作者：
OVERBECK, JR;BEACH, KW;STRANDNESS, DE
通讯作者：
STRANDNESS, DE
DOI：
10.1093/imammb/21.4.293
发表时间：
2004-12-01
影响因子：
1.1
作者：
Fogelson, AL;Guy, RD
通讯作者：
Guy, RD
影响因子：
10.4
作者：
Jackson, S. P.;Nesbitt, W. S.;Westein, E.
通讯作者：
Westein, E.
影响因子：
3.4
作者：
Mody, Nipa A.;King, Michael R.
通讯作者：
King, Michael R.
影响因子：
2.9
作者：
PHILLIPS, DJ;BEACH, KW;STRANDNESS, DE
通讯作者：
STRANDNESS, DE