Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design.
Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design.
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核糖体靶向抗生素：作用方式、耐药机制以及对药物设计的影响
DOI：
10.1146/annurev-biochem-062917-011942
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发表时间：
2018-06-20
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
遗传信息被核糖体翻译成蛋白质。核糖体及其与因子和抑制剂复合物的结构研究为蛋白质合成机制提供了宝贵的信息。核糖体抑制剂是最成功的抗微生物药物之一，占用于治疗感染的所有药物的一半以上。然而，细菌感染正变得越来越难以治疗，因为微生物已经适应对最有效的抗生素产生耐药性，对公共卫生保健构成重大威胁。这激发了对蛋白质合成抑制剂结构-功能研究的新兴趣，在少数情况下，化合物已被开发成对抗耐药病原体的有效治疗剂。在这篇综述中，我们描述了许多核糖体靶向抗生素的作用模式，重点介绍了致病菌产生的主要耐药机制，并讨论了新分子结构辅助设计的最新进展。
Genetic information is translated into proteins by the ribosome. Structural studies of the ribosome and of its complexes with factors and inhibitors have provided invaluable information on the mechanism of protein synthesis. Ribosome inhibitors are among the most successful antimicrobial drugs and constitute more than half of all medicines used to treat infections. However, bacterial infections are becoming increasingly difficult to treat because the microbes have adapted to become resistant to the most effective antibiotics, creating a major public health care threat. This has spurred a renewed interest in structure-function studies of protein synthesis inhibitors and, in few cases, compounds have been developed into potent therapeutic agents against drug-resistant pathogens. In this review, we describe the modes of action of many ribosome-targeting antibiotics, highlight the major resistance mechanisms developed by pathogenic bacteria, and discuss recent advances in structure-assisted design of new molecules.
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影响因子：
5.4
作者：
Arenz, Stefan;Wilson, Daniel N.
通讯作者：
Wilson, Daniel N.
影响因子：
4.5
作者：
Bommakanti, Ananth S.;Lindahl, Lasse;Zengel, Janice M.
通讯作者：
Zengel, Janice M.
DOI：
10.1073/pnas.071527498
发表时间：
2001-03-27
影响因子：
11.1
作者：
Belova, L;Tenson, T;Mankin, AS
通讯作者：
Mankin, AS
DOI：
10.1073/pnas.1501775112
发表时间：
2015-04-28
影响因子：
11.1
作者：
Arenz, Stefan;Nguyen, Fabian;Wilson, Daniel N.
通讯作者：
Wilson, Daniel N.
影响因子：
3.5
作者：
CERNA, J;RYCHLIK, I;LICHTENTHALER, FW
通讯作者：
LICHTENTHALER, FW