Percent fat mass is inversely associated with bone mass and hip geometry in rural Chinese adolescents.
Percent fat mass is inversely associated with bone mass and hip geometry in rural Chinese adolescents.
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脂肪质量百分比与中国青少年农村青少年的骨骼质量和髋关节几何形状成反比。
DOI：
10.1002/jbmr.40
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发表时间：
2010-07
期刊：
影响因子：
--
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Hong X;Arguelles LM;Liu X;Tsai HJ;Hsu YH;Wang B;Zhang S;Li Z;Tang G;Liu X;Yang J;Xu X;Langman C;Wang X
本研究试图在中国双胞胎队列中研究13 ~ 21岁的786名男性和618名女性的脂肪量百分比（PFM）与骨参数（尤其是髋部几何形状）之间的表型、遗传和环境相关性。采用双能X线骨密度仪测量骨密度、骨面积（BA）、骨矿含量（BMC）、骨横截面积（CSA）和骨横截模量（SM）。采用多元线性回归模型评估股骨髁-骨的关系。采用双生子设计的结构方程模型估计遗传/环境对个体表型和表型相关的影响。在控制体重和其他相关协变量后，我们观察到PFM和骨参数之间的负相关性：与PFM的最低年龄和性别特异性三分位数相比，PFM最高三分位数的男性具有较低的全身无头BA（WB-BA）、腰椎BA和腰椎BA。（L2-L4-BA）、全髋BA（TH-BA）、全髋BMC、CSA和SM（所有p < .005，校正p < .05）。除WB-BA和L2-L4-BA外，在雌性动物中观察到所有前述参数的相似负相关性。这些协会没有显着变化的坦纳阶段。在两种性别中，估计的遗传率分别为80%至86%的BMC，67%至80%的BA，74%至77%的CSA，和64%的SM。共同的遗传和环境因素的反向PFM骨相关性。我们的结论是，在这个样本的相对瘦的中国青少年，在给定的体重，PFM是负相关的BA，BMC，和髋关节几何形状在两种性别，这种协会是由于共同的遗传和环境因素。© 2010美国骨与矿物质研究学会。
This study was an attempt to examine the phenotypic, genetic, and environmental correlations between percent fat mass (PFM) and bone parameters, especially hip geometry, among 786 males and 618 females aged 13 to 21 years from a Chinese twin cohort. PFM, bone area (BA), bone mineral content (BMC), cross-sectional area (CSA), and section modulus (SM) were obtained by dual-energy X-ray absorptiometry. Multiple linear regression models were used to assess the PFM-bone relationships. A structural equation model for twin design was used to estimate genetic/environmental influences on individual phenotype and phenotypic correlations. After controlling for body weight and other pertinent covariates, we observed inverse associations between PFM and bone parameters: Compared with the lowest age- and gender-specific tertile of PFM, males in the highest tertile of PFM had lower measures of whole-body-less-head BA (WB-BA), lumbar spine BA (L2–L4-BA), total-hip BA (TH-BA), total-hip BMC, CSA, and SM (p < .005 for all, adjusted p < .05). Similar inverse associations were observed in females for all the preceding parameters except WB-BA and L2–L4-BA. These associations did not vary significantly by Tanner stages. In both genders, the estimated heritabilities were 80% to 86% for BMC, 67% to 80% for BA, 74% to 77% for CSA, and 64% for SM. Both shared genetics and environmental factors contributed to the inverse PFM-bone correlations. We conclude that in this sample of relatively lean Chinese adolescents, at a given body weight, PFM is inversely associated with BA, BMC, and hip geometry in both genders, and such associations are attributed to both shared genetic and environmental factors. © 2010 American Society for Bone and Mineral Research.
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影响因子：
6.2
作者：
Fairbrother, Una L.;Tanko, Laszlo B.;Blakemore, Alexandra I. F.
通讯作者：
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影响因子：
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DOI：
10.1210/jc.2006-0332
发表时间：
2006-07
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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