Adipose tissue stimulates bone growth in prepubertal children.
Adipose tissue stimulates bone growth in prepubertal children.
复制标题
脂肪组织刺激青春期前儿童的骨骼生长。
DOI：
10.1210/jc.2006-0332
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发表时间：
2006-07
期刊：
影响因子：
--
通讯作者：
Tobias JH
中科院分区：
文献类型：
--
作者：
Clark EM;Ness AR;Tobias JH
脂肪量对成人骨量具有积极影响，独立于瘦体重等其他因素，但类似的作用是否发生在儿童中尚不清楚。我们的目的是检查儿童脂肪量和骨量之间的关系。我们在大学研究诊所进行了综合横断面和前瞻性分析。参与者包括来自英格兰西南部大量人口出生队列的 9.9 岁儿童。通过 9.9 岁时的双能 X 射线吸收测定法测量全身脂肪量之间的关系，以及 1）9.9 岁时的全身无头部骨量和面积以及 2）接下来 2 年内骨量和面积的增加。即使在调整身高和/或瘦体重后，全身脂肪量与全身去头骨量和面积之间也存在很强的正相关关系（P < 0.001）。在接下来的两年里，男孩和 Tanner 1 期女孩的全身脂肪量与骨量和面积的增加之间存在类似的正相关关系。相比之下，Tanner 2 期女孩的脂肪量与骨量和体型增加之间不存在关联，而 Tanner 3 期女孩则出现负相关（青春期脂肪量相互作用，P < 0.001）。在青春期前的儿童中，脂肪量是骨量和大小以及这些参数在接下来的两年内增加的积极独立决定因素，这表明脂肪组织可以刺激骨骼生长。然而，这种关系随着青春期的到来而减弱。
Fat mass represents a positive influence on bone mass in adults, independently of other factors such as lean mass, but whether a similar action occurs in children is unclear. Our objective was to examine the relationship between fat mass and bone mass in children. We conducted combined cross-sectional and prospective analyses at university research clinics. Participants included children aged 9.9 yr from a large population-based birth cohort in southwest England. Relationships between total body fat mass were measured by dual-energy x-ray absorptiometry at age 9.9 yr, and 1) total-body-less-head bone mass and area at age 9.9 and 2) increase in bone mass and area over the following 2 yr. There was a strong positive relationship between total body fat mass and total-body-less-head bone mass and area, even after adjustment for height and/or lean mass (P < 0.001). There was a similar positive association between total body fat mass and increase in bone mass and area over the following 2 yr in boys and Tanner stage 1 girls. In contrast, no association was present between fat mass and gain in bone mass and size in Tanner stage 2 girls, whereas a negative association was seen in Tanner stage 3 girls (puberty-fat mass interaction, P < 0.001). In prepubertal children, fat mass is a positive independent determinant of bone mass and size and of increases in these parameters over the following 2 yr, suggesting that adipose tissue acts to stimulate bone growth. However, this relationship is attenuated by puberty.
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影响因子：
13.3
作者：
Porthouse, J;Birks, YF;Watt, I
通讯作者：
Watt, I
影响因子：
5.1
作者：
DREIZEN, S;SPIRAKIS, CN;STONE, RE
通讯作者：
STONE, RE
影响因子：
6.2
作者：
Clark, EM;Ness, A;Tobias, JH
通讯作者：
Tobias, JH
影响因子：
4.1
作者：
Crabtree, NJ;Kibirige, MS;Shaw, NJ
通讯作者：
Shaw, NJ
影响因子：
6.2
作者：
Goulding, A;Jones, IE;Williams, SM
通讯作者：
Williams, SM