New Insights into Mechanisms of Endocrine-Disrupting Chemicals in Thyroid Diseases: The Epigenetic Way.
New Insights into Mechanisms of Endocrine-Disrupting Chemicals in Thyroid Diseases: The Epigenetic Way.
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DOI：
10.3390/ijerph17217787
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发表时间：
2020-10-24
影响因子：
--
通讯作者：
Guzzolino E
中科院分区：
文献类型：
--
作者：
Pitto L;Gorini F;Bianchi F;Guzzolino E
近年来，环境中具有甲状腺干扰作用的化合物的存在正在逐渐增加。这一现象已经引起了人们对人类健康的关注，因为保持甲状腺系统的动态平衡对于胎儿发育和维持心理和生理健康至关重要。越来越多的研究探索了不同类别的毒物在甲状腺疾病的发生和严重程度中的作用，但大规模的流行病学研究有限，只有少数动物或体外研究试图确定化学作用的机制。最近，表观遗传学的改变，如甲基化状态的改变或非编码RNA的修改，被认为与可能导致易感个体不同甲状腺疾病的有害影响有关。本文旨在分析化学物质暴露引起的表观遗传学改变，并与甲状腺癌、自身免疫性甲状腺炎和胎儿甲状腺动态平衡紊乱等常见甲状腺疾病的发病有关。
In recent years, the presence in the environment of chemical compounds with thyroid-disrupting effects is progressively increased. This phenomenon has risen concern for human health as the preservation of thyroid system homeostasis is essential for fetal development and for maintaining psychological and physiological wellbeing. An increasing number of studies explored the role of different classes of toxicants in the occurrence and severity of thyroid diseases, but large epidemiological studies are limited and only a few animal or in vitro studies have attempted to identify the mechanisms of chemical action. Recently, epigenetic changes such as alteration of methylation status or modification of non-coding RNAs have been suggested as correlated to possible deleterious effects leading to different thyroid disorders in susceptible individuals. This review aims to analyze the epigenetic alterations putatively induced by chemical exposures and involved in the onset of frequent thyroid diseases such as thyroid cancer, autoimmune thyroiditis and disruption of fetal thyroid homeostasis.
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DOI：
10.1002/pros.23358
发表时间：
2017-06
期刊：
The Prostate
影响因子：
--
作者：
Armstrong CM;Liu C;Lou W;Lombard AP;Evans CP;Gao AC
通讯作者：
Gao AC
影响因子：
10.4
作者：
Bollati V;Marinelli B;Apostoli P;Bonzini M;Nordio F;Hoxha M;Pegoraro V;Motta V;Tarantini L;Cantone L;Schwartz J;Bertazzi PA;Baccarelli A
通讯作者：
Baccarelli A
影响因子：
5.1
作者：
Caumo, Sofia;Vicente, Ana;Vasconcellos, Perola
通讯作者：
Vasconcellos, Perola
影响因子：
3.9
作者：
Brown RL;de Souza JA;Cohen EE
通讯作者：
Cohen EE
影响因子：
5.8
作者：
Chan, S;Kachilele, S;Kilby, MD
通讯作者：
Kilby, MD