Control networks and neuromodulators of early development.

Control networks and neuromodulators of early development.
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DOI:
10.1037/a0025530
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发表时间:
2012-05
影响因子:
4
通讯作者:
Voelker P
Voelker P
中科院分区:
心理学2区
文献类型:
--
作者:
Posner MI;Rothbart MK;Sheese BE;Voelker P

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在成年人中,大多数认知和情绪的自我调节是由大脑区域网络进行的,包括前扣带回,前扣带回和基底神经节区域,与执行注意力有关。我们认为,在婴儿期,控制系统主要依赖于大脑网络参与定向的感觉事件,包括顶叶和额叶的领域。对成年人和警觉的猴子的研究表明,参与感觉事件定向的大脑网络主要由基底核中产生的烟碱胆碱能系统调节。执行注意网络主要由腹侧被盖区的多巴胺能输入调节。从胆碱能到多巴胺能调节的变化将是这种控制网络切换的结果,并且可能对理解早期发育很重要。我们跟踪的注意力,情绪和行为的变化,在早期发展相关的这种发展变化的调节网络及其调制器。
In adults most cognitive and emotional self-regulation is carried out by a network of brain regions, including the anterior cingulate, insula and areas of the basal ganglia, related to executive attention. We propose that during infancy control systems depend primarily upon a brain network involved in orienting to sensory events that includes areas of the parietal lobe and frontal eye fields. Studies of human adults and alert monkeys show that the brain network involved in orienting to sensory events is moderated primarily by the nicotinic cholinergic system arising in the nucleus basalis. The executive attention network is primarily moderated by dopaminergic input from the ventral tegmental area. A change from cholinergic to dopaminergic modulation would be a consequence of this switch of control networks and may be important in understanding early development. We trace the attentional, emotional and behavioral changes in early development related to this developmental change in regulative networks and their modulators.
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