Creating a model of diseased artery damage and failure from healthy porcine aorta.
Creating a model of diseased artery damage and failure from healthy porcine aorta.
复制标题
利用健康的猪主动脉创建患病动脉损伤和衰竭的模型。
DOI：
10.1016/j.jmbbm.2016.02.018
复制
发表时间：
2016
影响因子：
3.9
通讯作者：
Z. Taylor
中科院分区：
文献类型：
--
作者：
Christopher Noble;Nicole Smulders;N. Green;R. Lewis;M. Carré;S. E. Franklin;S. MacNeil;Z. Taylor
在新一代医疗器械的研究和开发中需要大量的患病组织，例如用于物理测试。然而，这些都很难获得。相比之下，猪动脉很容易获得，因为它们被视为废物。因此，从猪组织创建患病人体组织的物理模型的可靠手段将是有价值的，所述物理模型很好地模拟相关的机械变化。为此，我们研究了胶原酶、弹性蛋白酶和戊二醛处理猪胸主动脉对力学反应的影响。通过单轴拉伸试验评估机械和失效特性的变化。还采用了由Gasser-Ogden-Holzapfel模型（用于弹性响应）和连续损伤模型（用于失效）组成的本构模型，以提供进一步的比较基础（Calvo和佩纳，2006年，Gasser等人，2006年）。对于此处使用的浓度，发现：胶原酶处理的样品仅在轴向方向上显示出降低的断裂应力;弹性蛋白酶处理的样品仅在周向方向上显示出增加的断裂应力;戊二醛样品在两个方向上均未显示出变化。相对于所提出的本构模型，胶原酶和弹性蛋白酶对纤维相关的条款有很强的影响。该模型在圆周方向上更紧密地捕获了组织反应，因为在该方向上从损伤开始到完全失效的过渡更平滑和更尖锐。最后，将结果与病变组织的拉伸试验结果进行比较表明，这些治疗方法确实为创建病变动脉的物理模型提供了基础。
Large quantities of diseased tissue are required in the research and development of new generations of medical devices, for example for use in physical testing. However, these are difficult to obtain. In contrast, porcine arteries are readily available as they are regarded as waste. Therefore, reliable means of creating from porcine tissue physical models of diseased human tissue that emulate well the associated mechanical changes would be valuable. To this end, we studied the effect on mechanical response of treating porcine thoracic aorta with collagenase, elastase and glutaraldehyde. The alterations in mechanical and failure properties were assessed via uniaxial tension testing. A constitutive model composed of the Gasser-Ogden-Holzapfel model, for elastic response, and a continuum damage model, for the failure, was also employed to provide a further basis for comparison (Calvo and Pena, 2006, Gasser et al., 2006). For the concentrations used here it was found that: collagenase treated samples showed decreased fracture stress in the axial direction only; elastase treated samples showed increased fracture stress in the circumferential direction only; and glutaraldehyde samples showed no change in either direction. With respect to the proposed constitutive model, both collagenase and elastase had a strong effect on the fibre-related terms. The model more closely captured the tissue response in the circumferential direction, due to the smoother and sharper transition from damage initiation to complete failure in this direction. Finally, comparison of the results with those of tensile tests on diseased tissues suggests that these treatments indeed provide a basis for creation of physical models of diseased arteries.
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影响因子：
2.4
作者：
Teng, Zhongzhao;Tang, Dalin;Zheng, Jie;Woodard, Pamela K.;Hoffman, Allen H.
通讯作者：
Hoffman, Allen H.
影响因子：
6.9
作者：
O'Connell, Mary K.;Murthy, Sushila;Taylor, Charles A.
通讯作者：
Taylor, Charles A.
DOI：
--
发表时间：
2012
期刊：
Molecular & cellular biomechanics : MCB
影响因子：
--
作者：
Martinez,Ricky;Han,Hai-Chao
通讯作者：
Han,Hai-Chao
DOI：
10.1152/ajpheart.00463.2011
发表时间：
2012-02-01
影响因子：
4.8
作者：
Lee, Avione Y.;Han, Boyang;Han, Hai-Chao
通讯作者：
Han, Hai-Chao
影响因子：
9.7
作者：
Kamenskiy, Alexey V.;Pipinos, Iraklis I.;MacTaggart, Jason N.
通讯作者：
MacTaggart, Jason N.