An experimental study on the ultimate strength of the adventitia and media of human atherosclerotic carotid arteries in circumferential and axial directions.
An experimental study on the ultimate strength of the adventitia and media of human atherosclerotic carotid arteries in circumferential and axial directions.
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DOI：
10.1016/j.jbiomech.2009.07.009
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发表时间：
2009-11-13
影响因子：
2.4
通讯作者：
Hoffman, Allen H.
中科院分区：
文献类型：
--
作者：
Teng, Zhongzhao;Tang, Dalin;Zheng, Jie;Woodard, Pamela K.;Hoffman, Allen H.
动脉粥样硬化斑块可能会在没有警告的情况下破裂，导致心脏病发作或中风。了解人体动脉粥样硬化组织的极限强度对于理解破裂机制和预测心血管事件是必不可少的。尽管其非常重要，人类动脉粥样硬化颈动脉的极限强度的实验数据仍然非常稀少。本研究测定了含有II型和III型病变（AHA分类）的人颈动脉切片的单轴拉伸强度。从6条动脉制备轴向和周向外膜、中膜和完整样本（总计=73）。单轴拉伸的极限强度被认为是当试样显示出第一个破坏迹象时记录的峰值应力，并且延伸率被认为是破坏时的拉伸比。采用第一Piola-Kirchoff应力计算的外膜轴向和周向强度平均值分别为1996± 867 kPa和1802± 703 kPa，而中膜截面的相应值分别为519± 270 kPa和1230± 533 kPa。完整样本的极限强度与介质在周向方向上相似，但在轴向方向上是介质强度的两倍。结果还表明，外膜、中膜和完整样本在轴向和周向均表现出相似的断裂伸长率（拉伸比1.50 +/-0.22）。这些测量人类动脉粥样硬化颈动脉的材料强度极限可能有助于改善评估斑块易损性的计算模型。
Atherosclerotic plaque may rupture without warning causing heart attack or stroke. Knowledge of the ultimate strength of human atherosclerotic tissues is essential for understanding the rupture mechanism and predicting cardiovascular events. Despite its great importance, experimental data on ultimate strength of human atherosclerotic carotid artery remains very sparse. This study determined the uniaxial tensile strength of human carotid artery sections containing type II and III lesions (AHA classifications). Axial and circumferential oriented adventitia, media and intact specimens (total=73) were prepared from 6 arteries. The ultimate strength in uniaxial tension was taken as the peak stress recorded when the specimen showed the first evidence of failure and the extensibility was taken as the stretch ratio at failure. The mean adventitia strength values calculated using the 1st Piola-Kirchoff stress were 1996±867kPa and 1802±703kPa in the axial and circumferential directions respectively, while the corresponding values for the media sections were 519±270kPa and 1230±533kPa. The intact specimens showed ultimate strengths similar to media in circumferential direction but were twice as strong as the media in the axial direction. Results also indicated that adventitia, media and intact specimens exhibited similar extensibility at failure, in both the axial and circumferential directions (stretch ratio 1.50 +/−0.22). These measurements of the material strength limits for human atherosclerotic carotid arteries could be useful in improving computational models that assess plaque vulnerability.
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影响因子：
5.3
作者：
LENDON, CL;DAVIES, MJ;RICHARDSON, PD
通讯作者：
RICHARDSON, PD
影响因子：
2
作者：
Holzapfel, GA;Gasser, TC;Ogden, RW
通讯作者：
Ogden, RW
影响因子：
2.2
作者：
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通讯作者：
Sloten, Jos Vander
DOI：
10.1115/1.1800557
发表时间：
2004-10-01
影响因子：
1.7
作者：
Holzapfel, GA;Sommer, G;Regitnig, P
通讯作者：
Regitnig, P
DOI：
10.1115/1.2073668
发表时间：
2005-12-01
影响因子：
1.7
作者：
Tang, DL;Yang, C;Yuan, C
通讯作者：
Yuan, C